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PHOTOBLEACHING OF PORPHYRINS USED IN PHOTODYNAMIC THERAPY AND IMPLICATIONS FOR THERAPY
Abstract
Abstract— The development of an extraction procedure to quantitate dihematoporphyrin ether (DHE) concentration in tissues correlated to fluorescence measurements from instrumentation developed for in vivo fluorimetry was examined. In vivo fluorometric results from mouse mammary carcinoma (SMT‐F) were calibrated against results of the chemical extraction assay quantitated spectrophotometrically. Fluorescence and drug extractable levels increase in a linear fashion with injected dose. Loss of porphyrin fluorescence (photobleaching) and intra‐tumoral porphyrin level has been demonstrated both in vitro (NHIK cells) and in vivo (SMT‐F tumor) during illumination with light following exposure to Hpd or DHE. This process is essentially independent of porphyrin tumor level in vivo and could lead to tumor protection at very low porphyrin levels. On the other hand, this photobleaching process which occurs concurrent with cellular inactivation and tissue damage due to the photodynamic process can be exploited to protect normal tissue during photodynamic therapy (PDT) and thus greatly enhance the therapeutic ratio. This has been demonstrated in patients undergoing PDT.
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HOW DOES PHOTODYNAMIC THERAPY WORK?
Henderson, B. W., & Dougherty, T. J. (1992) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1992.tb04222.x · Cited by 2,358
Self-citationPhotodynamic therapy in dermatology
Kalka, K., Merk, H., & Mukhtar, H. (2000) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(00)90209-3 · Cited by 522
Oxygen Consumption and Diffusion Effects in Photodynamic Therapy
Foster, T. H., Murant, R. S., Bryant, R. G., Knox, R. S., Gibson, S. L., & Hilf, R. (1991) · Radiation Research · doi:10.2307/3577919 · Cited by 400
5‐ALA in the management of malignant glioma
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Metadata
- Authors
- Mang, T. S., Dougherty, T. J., Potter, W. R., Boyle, D. G., Somer, S., & Moan, J.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1987-04
- Volume
- 45
- Issue
- 4
- Pages
- 501-506
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2127298293
- Cited by
- 269
- References
- 0
- FWCI
- 19.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: PHOTOBLEACHING OF PORPHYRINS USED IN PHOTODYNAMIC THERAPY AND IMPLICATIONS FOR THERAPY. https://app.cochat.ai/papers/10.1111/j.1751-1097.1987.tb05409.x
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- Mang, T. S., Dougherty, T. J., Potter, W. R., Boyle, D. G., Somer, S., & Moan, J. (1987). PHOTOBLEACHING OF PORPHYRINS USED IN PHOTODYNAMIC THERAPY AND IMPLICATIONS FOR THERAPY. Photochemistry and Photobiology. https://doi.org/10.1111/j.1751-1097.1987.tb05409.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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