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In vivo TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULPHONATED PHTHALOCYANINE
Abstract
Abstract— In its simplest form, the photodynamic therapy (PDT) threshold dose model states that tissue necrosis due to PDT will occur if the number of photons absorbed by the photosensitizer per unit volume of tissue exceeds a critical value. This threshold is given by the product of photon fluence, photosensitizer concentration and specific absorption coefficient. To test the validity of this concept for PDT of normal rat liver sensitized with aluminum chlorosulphonated phthalocyanine (AISPC), all three of these parameters were varied by changing the injected AISPC dose, the wavelength of excitation and the irradiation geometry. The extent of necrosis caused by the treatment was consistent with the threshold model, except when the concentration of AlSPC in the liver exceeded 20 μg g−1. For this animal model, we estimate the threshold to be (3.8 ± 0.2) x 10 19 photons cm −3
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Cited by
HOW DOES PHOTODYNAMIC THERAPY WORK?
Henderson, B. W., & Dougherty, T. J. (1992) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1992.tb04222.x · Cited by 2,358
Photophysical and photobiological processes in the photodynamic therapy of tumours
Ochsner, M. (1997) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/s1011-1344(96)07428-3 · Cited by 1,081
Implicit and explicit dosimetry in photodynamic therapy: a New paradigm
Wilson, B. C., Patterson, M. S., & Lilge, L. (1997) · Lasers in Medical Science · doi:10.1007/bf02765099 · Cited by 411
Self-citationOxygen Consumption and Diffusion Effects in Photodynamic Therapy
Foster, T. H., Murant, R. S., Bryant, R. G., Knox, R. S., Gibson, S. L., & Hilf, R. (1991) · Radiation Research · doi:10.2307/3577919 · Cited by 400
Niedre, M., Patterson, M. S., & Wilson, B. C. (2002) · Photochemistry and Photobiology · doi:10.1562/0031-8655(2002)0750382dnildo2.0.co2 · Cited by 396
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Metadata
- Authors
- Patterson, M. S., Wilson, B. C., & Graff, R.
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1990-03
- Volume
- 51
- Issue
- 3
- Pages
- 343-349
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W1996004688
- Cited by
- 198
- References
- 0
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Patterson, M. S., Wilson, B. C., & Graff, R. (1990). In vivo TESTS OF THE CONCEPT OF PHOTODYNAMIC THRESHOLD DOSE IN NORMAL RAT LIVER PHOTOSENSITIZED BY ALUMINUM CHLOROSULPHONATED PHTHALOCYANINE. Photochemistry and Photobiology. https://doi.org/10.1111/j.1751-1097.1990.tb01720.x
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