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PENETRATION POTENCY OF TOPICAL APPLIED δ‐AMINOLEVULINIC ACID FOR PHOTODYNAMIC THERAPY OF BASAL CELL CARCINOMA *
Abstract
Abstract Penetration potency of δ‐aminolevulinic acid (ALA) was studied by examining fluorescence of endogenous protoporphyrin IX in different histological types of basal cell carcinoma. Ten basal cell carcinomas were coated with an ointment containing 10% ALA prior to excision; five served as controls. Tumors were excised either 4 h or 12 h after application of ALA using a modified Mohs’micrographic surgical technique. Horizontal sections were cut from deep dermis to tumor surface and examined under a fluorescence microscope. After 4 h of application, only skin appendages demonstrated fluorescence typical of protoporphyrin IX. After 12 h, fluorescence was detectable in tumor cells in deep dermis. The five controls revealed no fluorescence at any site. These results may confirm the high penetration potential of topically applied ALA and its usefulness in photodynamic therapy. For tumors penetrating to deep dermis, an application time of more than 4 h seems necessary, at least when hydrophilic solvents for ALA are used.
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“In terms of topical ALA administration it should be emphasized that due to the fact that stratum corneum is the most important barrier for ALA skin penetration, the PpIX fluorescence is observed only at a depth of 0.3 to 0.6 mm [56,57,58].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [56]
Citations
Cites
Photodynamic therapy with endogenous protoporphyrin
Kennedy, J. C., Pottier, R. H., & Pross, D. C. (1990) · Journal of Photochemistry and Photobiology B: Biology · doi:10.1016/1011-1344(90)85083-9 · Cited by 1,509
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Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer
Wachowska, M., Muchowicz, A., Firczuk, M., Gabrysiak, M., Winiarska, M., Wańczyk, M., Bojarczuk, K., & Golab, J. (2011) · Molecules · doi:10.3390/molecules16054140 · Cited by 265
Wennberg, A.-M., Larkö, O., Lönnroth, P., Larson, G., & Krogstad, A.-L. (2000) · Clinical and Experimental Dermatology · doi:10.1046/j.1365-2230.2000.00652.x · Cited by 48
Metadata
- Authors
- Szeimies, R., Sassy, T., & Landthaler, M.
- Affiliations
- University of Regensburg (DE)
- Helmholtz Munich (DE)
- Corresponding author
- Szeimies, Rolf‐Markus
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 1994-01
- Volume
- 59
- Issue
- 1
- Pages
- 73-76
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2109980613
- Cited by
- 132
- References
- 1
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 2
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Photodynamic Therapy Research Studies
- Health Sciences › Medicine › Dermatology › Nonmelanoma Skin Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Porphyrin Metabolism and Disorders
- Keywords
- 5-aminolevulinic acid, topical application, skin penetration, photodynamic therapy, basal cell carcinoma, protoporphyrin IX fluorescence, Mohs micrographic surgery, application time, deep dermis, hydrophilic solvents
- MeSH terms
- Administration, Topical, Aminolevulinic Acid, Basal Cell Carcinoma, Carcinoma, Basal Cell, Humans, Microscopy, Fluorescence, Photochemotherapy, Protoporphyrins, Skin Neoplasms
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- CoChat. (2026). Citation check: PENETRATION POTENCY OF TOPICAL APPLIED δ‐AMINOLEVULINIC ACID FOR PHOTODYNAMIC THERAPY OF BASAL CELL CARCINOMA *. https://app.cochat.ai/papers/10.1111/j.1751-1097.1994.tb05003.x
- The paper
- Szeimies, R., Sassy, T., & Landthaler, M. (1994). PENETRATION POTENCY OF TOPICAL APPLIED δ‐AMINOLEVULINIC ACID FOR PHOTODYNAMIC THERAPY OF BASAL CELL CARCINOMA *. Photochemistry and Photobiology. https://doi.org/10.1111/j.1751-1097.1994.tb05003.x
