Ultraviolet‐A Irradiation to the Eye Modulates Intestinal Mucosal Functions and Properties of Mast Cells in the Mouse
Abstract
We previously reported that topical irradiation of the eye by ultraviolet‐B (UVB) activated hypothalamo‐pituitary‐adrenal axis (HPA‐A) of the mouse to increase 3, 4‐dihydroxyphenylalanine (DOPA)‐positive melanocytes in the skin by an inducible nitric oxide synthase (iNOS)‐dependent mechanism. This work demonstrates that irradiation of the eye by ultraviolet‐A (UVA) specifically increased DOPA‐positive cells in the mucosa of the jejunum and colon of C57BL/6J mice by some HPA‐ and iNOS‐independent mechanism. UVA‐induced increase in DOPA‐positive cells in the intestine was inhibited by the administration of hexamethonium or prazosin plus propranolol, blockers for the sympathetic nervous system. UVA irradiation of the eye increased DOPA‐ and histidine decarboxylase (HDC)‐positive cells in the intestinal mucosa of both C57BL/6J and WBB6F1/J mice but not in the mutant strain W/Wv of the latter that lack mast cells. UVA irradiation of the eye suppressed the intestinal peristalsis of control, hypophysectomized or iNOS−/− C57BL/6J mice by the mechanism that was inhibited by hexamethonium or prazosin plus propranolol. These observations suggest that UVA irradiation of the eye stimulated the sympathetic nervous system to increase the mucosal DOPA‐ and HDC‐positive mast cells and suppressed the peristalsis of the small intestine of the mouse.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
UVA had no effect on cortisol, CRH, and ACTH production but stimulated β-endorphin and 11βHSD2 expression.
“UVA (320–400 nm) had no effect on cortisol, CRH and ACTH production but stimulated β-endorphin and 11βHSD2 expression [81, 151, 155].”
From Steroidogenesis in the skin: Implications for local immune functions (2013) · cites this paper as [155]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cited by
Sorted by citations
How UV Light Touches the Brain and Endocrine System Through Skin, and Why
Slominski, A. T., Zmijewski, M. A., Plonka, P. M., Szaflarski, J. P., & Paus, R. (2018) · Endocrinology · doi:10.1210/en.2017-03230 · Cited by 452 · see citing works
Steroidogenesis in the skin: Implications for local immune functions
Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369 · see citing works
- Authors
- Yamate, Y., Hiramoto, K., Kasahara, E., Jikumaru, M., Sato, E. F., Inoue, J., & Inoue, M.
- Affiliations
- Osaka City University (JP)
- Corresponding author
- Inoue, Masayasu
- Venue
- Photochemistry and Photobiology
- Publisher
- Wiley
- Published
- 2010-11-12
- Volume
- 87
- Issue
- 1
- Pages
- 191-198
- ISSN
- 0031-8655 (ISSN-L)
- 1751-1097
- OpenAlex
- W2029002262
- Cited by
- 11
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2018: 1 · 2014: 4 · 2013: 2
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Photochemistry and Photobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- UVA irradiation, mast cells, intestinal mucosa, histidine decarboxylase, sympathetic nervous system, hypothalamic-pituitary-adrenal axis, intestinal peristalsis, hexamethonium, prazosin, propranolol, melanocytes
- MeSH terms
- Animals, Eye, Intestinal Mucosa, Male, Mast Cells, Mice, Inbred C57BL, Ultraviolet Rays, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
