The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases
Open accessAbstract
Summary: Haptoglobin (Hp) is a plasma α2‐glycoprotein which binds free haemoglobin, thus preventing oxidative damage. The complex is rapidly removed from the circulation by a specific receptor (CD163) found on macrophages. Three major subtypes, Hp1‐1, Hp2‐1 and Hp2‐2 are the product of two closely related genes HP 1 and HP 2. The frequency of the HP 1 and HP 2 genes varies worldwide depending on racial origin: the HP 1 frequency varying from about 0.07 in parts of India to over 0.7 in parts of West Africa and South America. Both HP 1 and HP 2 have been linked to susceptibility to various diseases. Such associations may be explained by functional differences between the subtypes in the binding of Hb and its rate of clearance from the plasma. However, there are also corresponding negative reports for disease associations. The conflicting evidence on disease association and the lack of association between disease and particular populations, despite the wide range of HP 1 and HP 2 gene frequencies across the world, may indicate that any associations are marginal.
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Cites
Acute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734
Philippidis, P., Mason, J. C., Evans, B. J., Nadra, I., Taylor, K. M., Haskard, D. O., & Landis, R. C. (2004) · Circulation Research · doi:10.1161/01.res.0000109414.78907.f9 · Cited by 476
Biological activity of nitric oxide in the plasmatic compartment
Wang, X., Tanus-Santos, J. E., Reiter, C. D., Dejam, A., Shiva, S., Smith, R. D., Hogg, N., & Gladwin, M. T. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402201101 · Cited by 164
Cited by
Sturgeon, C., & Fasano, A. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1251384 · Cited by 497
Vercaemst, L. (2008) · The Journal of ExtraCorporeal Technology · doi:10.1051/ject/200840257 · Cited by 269
Identification of genetic variants influencing the human plasma proteome
Johansson, Å., Enroth, S., Palmblad, M., Deelder, A. M., Bergquist, J., & Gyllensten, U. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217238110 · Cited by 82
Metadata
- Authors
- CARTER, K., & WORWOOD, M.
- Venue
- International Journal of Laboratory Hematology
- Publisher
- Wiley
- Published
- 2007-03-06
- Volume
- 29
- Issue
- 2
- Pages
- 92-110
- ISSN
- 1751-5521 (ISSN-L)
- 1751-553X
- OpenAlex
- W1567895031
- Cited by
- 222
- References
- 3
- FWCI
- 4.59
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CARTER, K., & WORWOOD, M. (2007). Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases. International Journal of Laboratory Hematology. https://doi.org/10.1111/j.1751-553x.2007.00898.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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