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The Comparative Effects of Azilsartan Medoxomil and Olmesartan on Ambulatory and Clinic Blood Pressure
Open accessAbstract
The current study assesses the antihypertensive efficacy and safety of the investigational angiotensin receptor blocker (ARB), azilsartan medoxomil (AZL‐M), compared with placebo and the ARB olmesartan medoxomil (OLM‐M). This randomized, double‐blind, placebo‐controlled, multicenter study assessed change from baseline in mean 24‐hour ambulatory systolic blood pressure (SBP) following 6 weeks of treatment. Patients with primary hypertension ( n =1275) and baseline 24‐hour mean ambulatory systolic pressure ≥130 mm Hg and ≤170 mm Hg were studied; 142 received placebo and the remainder received 20 mg, 40 mg, or 80 mg AZL‐M or 40 mg OLM‐M. Mean age of participants was 58±11 years, baseline mean 24‐hour SBP was 146 mm Hg. Dose‐dependent reductions in 24‐hour mean SBP at study end occurred in all AZL‐M groups. Reduction in 24‐hour mean SBP was greater with AZL‐M 80 mg than OLM‐M 40 mg by 2.1 mm Hg (95% confidence interval, −4.0 to −0.1; P=.038), while AZL‐M 40 mg was noninferior to OLM‐M 40 mg. The side effect profiles of both ARBs were similar to placebo. AZL‐M is well tolerated and more efficacious at its maximal dose than the highest dose of OLM‐M. J Clin Hypertens (Greenwich). 2011;13:81–88. © 2011 Wiley Periodicals, Inc.
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“Specifically, 24-hour ABPM studies demonstrate that azilsartan medoximil provides on average an additional 4 to 8 mm Hg further SBP reduction over other ARBs (eg, valsartan and olmesartan) or the ACE inhibitor ramipril.381–383”
From Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association (2018) · cites this paper as [382]
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Cites
Ahmed, A., Jorna, T., & Bhandari, S. (2016) · The Nephron journals/Nephron journals · doi:10.1159/000447068 · Cited by 11,782
Brenner, B. M., Cooper, M. E., de Zeeuw, D., Keane, W. F., Mitch, W. E., Parving, H.-H., Remuzzi, G., Snapinn, S. M., Zhang, Z., & Shahinfar, S. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011161 · Cited by 7,493
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333
Lewis, E. J., Hunsicker, L. G., Clarke, W. R., Berl, T., Pohl, M. A., Lewis, J. B., Ritz, E., Atkins, R. C., Rohde, R., & Raz, I. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011303 · Cited by 5,987
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595
US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008
Egan, B. M. (2010) · JAMA · doi:10.1001/jama.2010.650 · Cited by 2,197
Pfeffer, M. A., Swedberg, K. B., Granger, C. B., Held, P., McMurray, J. J. V., Michelson, E. L., Olofsson, B., Östergren, J., & Yusuf, S. (2003) · The Lancet · doi:10.1016/s0140-6736(03)14282-1 · Cited by 1,895
Pitt, B., Segal, R., Martínez, F. A., Meurers, G., Cowley, A. J., Thomas, I., DEEDWANIA, P. C., Ney, D. E., Snavely, D. B., & Chang, P. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01187-2 · Cited by 1,660
Blood Pressure Lowering Treatment Trialists’ Collaboration (2008) · BMJ · doi:10.1136/bmj.39548.738368.be · Cited by 739
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Carey, R. M., Calhoun, D. A., Bakris, G. L., Brook, R. D., Daugherty, S. L., Dennison-Himmelfarb, C. R., Egan, B. M., Flack, J. M., Gidding, S. S., Judd, E., et al. (2018) · Hypertension · doi:10.1161/hyp.0000000000000084 · Cited by 1,153
Self-citationThe past, present and future of renin–angiotensin aldosterone system inhibition
Mentz, R. J., Bakris, G. L., Waeber, B., McMurray, J. J. V., Gheorghiade, M., Ruilope, L. M., Maggioni, A. P., Swedberg, K. B., Piña, I. L., Fiuzat, M., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2012.10.007 · Cited by 121
Self-citationSica, D. A., White, W. B., Weber, M. A., Bakris, G. L., Pérez, A., Cao, C., Handley, A., & Kupfer, S. (2011) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2011.00482.x · Cited by 117
“There was a greater likelihood of serum creatinine transiently increasing at any postbaseline visit, a finding not unexpected with the significant BP reduction seen with a potent ARB.(21,22) This finding is likely due to BP-related alterations in renal hemodynamics, as has been previously described in patients treated…”
BackgroundSelf-citationRakugi, H., Enya, K., Sugiura, K., & Ikeda, Y. (2012) · Hypertension Research · doi:10.1038/hr.2012.8 · Cited by 114
Angiotensin Receptor Blockers: Pharmacology, Efficacy, and Safety
Taylor, A. A., Siragy, H. M., & Nesbitt, S. D. (2011) · Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2011.00518.x · Cited by 103
“In a companion study, changes in placebo-subtracted trough seated systolic BP in each of 4 active treatment groups (AZL 20 mg, 40 mg, and 80 mg daily and olmesartan medoxomil 40 mg daily) were similar to the changes in mean ambulatory systolic pressure.(40)”
Result
Metadata
- Authors
- Bakris, G. L., Sica, D., Weber, M., White, W. B., Roberts, A., Perez, A., Cao, C., & Kupfer, S.
- Affiliations
- University of Connecticut (US)
- State University of New York (US)
- Corresponding author
- Bakris, George L.
- Venue
- The Journal of Clinical Hypertension
- Publisher
- Wiley
- Published
- 2011-01-27
- Volume
- 13
- Issue
- 2
- Pages
- 81-88
- ISSN
- 1524-6175 (ISSN-L)
- 1751-7176
- PMC
- PMC8673073
- OpenAlex
- W2077469844
- Cited by
- 143
- References
- 24
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 13 · 2019: 4 · 2018: 12 · 2017: 9 · 2016: 16 · 2015: 7 · 2014: 5 · 2013: 19 · 2012: 21
- FWCI
- 11.85
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Abbott Laboratories
- Bristol-Myers Squibb
- Eli Lilly and Company
- AstraZeneca
- PepsiCo
- Gilead Sciences
- FibroGen
- Savient Pharmaceuticals
- Daiichi-Sankyo
- Astellas Pharma
- Servier
- Daiichi Sankyo Europe
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Keywords
- azilsartan medoxomil, olmesartan medoxomil, angiotensin receptor blockers, antihypertensive efficacy, essential hypertension, 24-hour ambulatory blood pressure, systolic blood pressure, dose-response relationship, drug safety, non-inferiority
- MeSH terms
- Aged, Argentina, Benzimidazoles, Blood Pressure, Blood Pressure Determination, Double-Blind Method, Female, Humans, Hypertension, Imidazoles, Male, Mexico, Middle Aged, Oxadiazoles, Peru, Tetrazoles, United States, Treatment Outcome, Blood Pressure Monitoring, Ambulatory, Racial Groups, Angiotensin Receptor Antagonists
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