Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 527

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Scientific Evidence of Interventions Using the Mediterranean Diet: A Systematic Review

Serra-Majem, Lluís, Roman, Blanca, Estruch, Ramón·2006·Nutrition Reviews
DOI 10.1111/j.1753-4887.2006.tb00232.x
Open this paper in CoChat — free account

Abstract

The Mediterranean Diet has been associated with greater longevity and quality of life in epidemiological studies, the majority being observational. The application of evidence-based medicine to the area of public health nutrition involves the necessity of developing clinical trials and systematic reviews to develop sound recommendations. The purpose of this study was to analyze and review the experimental studies on Mediterranean diet and disease prevention. A systematic review was made and a total of 43 articles corresponding to 35 different experimental studies were selected. Results were analyzed for the effects of the Mediterranean diet on lipoproteins, endothelial resistance, diabetes and antioxidative capacity, cardiovascular diseases, arthritis, cancer, body composition, and psychological function. The Mediterranean diet showed favorable effects on lipoprotein levels, endothelium vasodilatation, insulin resistance, metabolic syndrome, antioxidant capacity, myocardial and cardiovascular mortality, and cancer incidence in obese patients and in those with previous myocardial infarction. Results disclose the mechanisms of the Mediterranean diet in disease prevention, particularly in cardiovascular disease secondary prevention, but also emphasize the need to undertake experimental research and systematic reviews in the areas of primary prevention of cardiovascular disease, hypertension, diabetes, obesity, infectious diseases, age-related cognitive impairment, and cancer, among others. Interventions should use food scores or patterns to ascertain adherence to the Mediterranean diet. Further experimental research is needed to corroborate the benefits of the Mediterranean diet and the underlying mechanisms, and in this sense the methodology of the ongoing PREDIMED study is explained.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1111/j.1753-4887.2006.tb00232.x

Cites

6 of 6 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 59

  1. Tunstall-Pedoe, 1999, Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10 years results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease, Lancet, 353, S1547, 10.1016/S0140-6736(99)04021-0 · DOI · Paper page
  2. Masia, 1998, High prevalence of cardiovascular risk factors in Gerona, Spain, a province with low myocardial infarction incidence. REGICOR investigators, J Epidemiol Comm Health, 52, S707, 10.1136/jech.52.11.707 · DOI · Paper page
  3. Helsing, 1989, The Mediterranean diet and food culture: a symposium, Eur J Clin Nutr, 43, S1
  4. Serra Majem, 1993, Changing patterns of fat intake in Mediterranean countries, Eur J Clin Nutr, 47, S1
  5. Nestle, 1995, Mediterranean diets: science and policy implications, Am J Clin Nutr, 61, S1313, 10.1093/ajcn/61.6.1313S · DOI · Paper page
  6. Willett, 1995, Mediterranean diet pyramid: a cultural model for healthy eating, Am J Clin Nutr, 61, S1402, 10.1093/ajcn/61.6.1402S · DOI · Paper page
  7. Trichopoulou, 1997, Healthy traditional Mediterranean diet: an expression of culture, history, and lifestyle, Nutr Rev, 55, S383, 10.1111/j.1753-4887.1997.tb01578.x · DOI · Paper page
  8. 9. Serra MajemL., NgoJ. (eds) Que es la dieta Mediterranea?.Barcelona: Nexus Ediciones 2002:S1-S221.
  9. Serra Majem, 2004, Foreword: does the definition of the Mediterranean diet need to be updated, Public Health Nutr, 7, S927, 10.1079/PHN2004564 · DOI
  10. Vincent, 2004, The Medi-RIVAGE study (Mediterranean diet, cardiovascular risks and gene polymorphisms): rationale, recruitment, design, dietary intervention and baseline characteristics of participants, Public Health Nutr, 7, S531, 10.1079/PHN2003547 · DOI
  11. Esposito, 2004, Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial, JAMA, 292, S1440, 10.1001/jama.292.12.1440 · DOI · Paper page
  12. Ros, 2004, A walnut diet improves endothelial function in hypercholester-olemic subjects: a randomized crossover trial, Circulation, 109, S1609, 10.1161/01.CIR.0000124477.91474.FF · DOI · Paper page
  13. Ambring, 2004, Effects of a Mediterranean-inspired diet on blood lipids, vascular function and oxidative stress in healthy subjects, Clin Sci, 106, S519, 10.1042/CS20030315 · DOI
  14. Goulet, 2004, Effect of a nutritional intervention promoting the Mediterranean food pattern on electrophoretic characteristics of low-density lipoprotein particles in healthy women from the Quebec City metropolitan area, Br J Nutr, 92, S285, 10.1079/BJN20041198 · DOI
  15. Flynn, 2004, Mediterranean diet improves lipid profiles over three months, Asia Pac J Clin Nutr, 13, S138
  16. Urquiaga, 2004, Effect of Mediterranean and occidental diets, and red wine, on plasma fatty acids in humans. An intervention study, Biol Res, 37, S253, 10.4067/S0716-97602004000200012 · DOI
  17. Bravo-Herrera, 2004, Tissue factor expression is decreased in monocytes obtained from blood during Mediterranean or high carbohydrate diets, Nutr Metab Cardiovasc Dis, 14, S128, 10.1016/S0939-4753(04)80032-2 · DOI
  18. Rodríguez-Villar, 2004, Comparison of a high-carbohydrate and a high monounsaturated fat, olive oil-rich diet on the susceptibility of LDL to oxidative modification in subjects with type 2 diabetes mellitus, Diabet Med, 21, S142, 10.1046/j.1464-5491.2003.01086.x · DOI · Paper page
  19. Goulet, 2003, Effect of a nutritional intervention promoting the Mediterranean food pattern on plasma lipids, lipoproteins and body weight in healthy French-Canadian women, Atherosclerosis, 170, S115, 10.1016/S0021-9150(03)00243-0 · DOI
  20. Sondergaard, 2003, Effect of dietary intervention and lipid-lowering treatment on brachial vasoreactivity in patients with ischemic heart disease and hypercholesterolemia, Am Heart J, 145, S19, 10.1016/S0002-8703(03)00078-4 · DOI
  21. Mezzano, 2003, Mediterranean diet, but not red wine, is associated with beneficial changes in primary haemostasis, Eur J Clin Nutr, 57, S439, 10.1038/sj.ejcn.1601558 · DOI
  22. Singh, 2002, Effects of a ‘healthy’ diet and of acute and long-term vitamin C on vascular function in healthy older subjects, Cardiovasc Res, 56, S118, 10.1016/S0008-6363(02)00514-X · DOI
  23. Mezzano, 2001, Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors, Eur J Clin Nutr, 55, S444, 10.1038/sj.ejcn.1601202 · DOI
  24. Fuentes, 2001, Mediterranean and low-fat diets improve endothelial function in hypercholesterolemic men, Ann Intern Med, 134, S1115, 10.7326/0003-4819-134-12-200106190-00011 · DOI · Paper page
  25. Munoz, 2001, Walnut-enriched diet increases the association of LDL from hypercholesterolemic men with human HepG2 cells, J Lipid Res, 42, S2069, 10.1016/S0022-2275(20)31536-4 · DOI
  26. Zambon, 2000, Substituting walnuts for monounsaturated fat improves the serum lipid profile of hypercholesterolemic men and women. A randomized crossover trial, Ann Intern Med, 132, S538, 10.7326/0003-4819-132-7-200004040-00005 · DOI · Paper page
  27. Madigan, 2000, Dietary unsaturated fatty acids in type 2 diabetes: higher levels of postprandial lipoprotein on a linoleic acid-rich sunflower oil diet compared with an oleic acid-rich olive oil diet, Diabetes Care, 23, S1472, 10.2337/diacare.23.10.1472 · DOI
  28. Ryan, 2000, Diabetes and the Mediterranean diet: a beneficial effect of oleic acid on insulin sensitivity, adipocyte glucose transport and endothelium-dependent vasoreactivity, QJM, 93, S85, 10.1093/qjmed/93.2.85 · DOI
  29. Barbagallo, 1999, Effects of Mediterranean diet on lipid levels and cardiovascular risk in renal transplant recipients, Nephron, 82, S199, 10.1159/000045403 · DOI
  30. Leighton, 1999, A. Plasma polyphenols and antioxidants, oxidative DNA damage and endothelial function in a diet and wine intervention study in humans, Drugs Exp Clin Res, 25, S133
  31. Perez-Jimenez, 1999, Circulating levels of endothelial function are modulated by dietary monounsaturated fat, Atherosclerosis, 145, S351, 10.1016/S0021-9150(99)00116-1 · DOI
  32. Baroni, 1999, Solid monounsaturated diet lowers LDL unsaturation trait and oxidisability in hypercholesterolemic (type IIb) patients, Free Radic Res, 30, S275, 10.1080/10715769900300301 · DOI
  33. Simoni, 1995, Gemfibrozil and Mediterranean diet for patients with high plasma levels of lipoprotein [Lp(a)] and cholesterol-pilot study, Cardiovasc Drugs Ther, 9, S347, 10.1007/BF00878680 · DOI
  34. Salen, 1994, Effects of a French Mediterranean diet on heart transplant recipients with hypercholesterolemia, Am J Cardiol, 73, S825, 10.1016/0002-9149(94)90890-7 · DOI
  35. Moreno Vazquez, 1994, Influence of diet and physical exercise on plasma lipid concentrations in an homogeneous sample of young Spanish air force pilots, Eur J Appl Physiol Occup Physiol, 69, S75, 10.1007/BF00867931 · DOI
  36. Ferro-Luzzi, 1984, Changing the Mediterranean diet: effects on blood lipids, Am J Clin Nutr, 40, S1027, 10.1093/ajcn/40.5.1027 · DOI
  37. Ehnholm, 1982, Effect of diet on serum lipoproteins in a population with a high risk of coronary heart disease, N Engl J Med, 307, S850, 10.1056/NEJM198209303071403 · DOI
  38. Barzi, 2003, Mediterranean diet and all-causes mortality after myocardial infarction: results from the GISSI-Prevenzione trial, Eur J Clin Nutr, 57, S604, 10.1038/sj.ejcn.1601575 · DOI
  39. Lorgeril, 1999, Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study, Circulation, 99, S779, 10.1161/01.CIR.99.6.779 · DOI · Paper page
  40. Lorgeril, 1996, Effect of a Mediterranean type of diet on the rate of cardiovascular complications in patients with coronary artery disease. Insights into the cardioprotective effect of certain nutriments, J Am Coll Cardiol, 28, S1103, 10.1016/S0735-1097(96)00280-X · DOI
  41. Lorgeril, 1994, Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease, Lancet, 343, S1454, 10.1016/S0140-6736(94)92580-1 · DOI · Paper page
  42. Skoldstam, 2003, An experimental study of a Mediterranean diet intervention for patients with rheumatoid arthritis, Ann Rheum Dis, 62, S208, 10.1136/ard.62.3.208 · DOI · Paper page
  43. Hagfors, 2003, Anti-oxidant intake, plasma antioxidants and oxidative stress in a randomized, controlled, parallel, Mediterranean dietary intervention study on patients with rheumatoid arthritis, Nutr J, 2, S5, 10.1186/1475-2891-2-5 · DOI
  44. Lorgeril, 1998, Mediterranean dietary pattern in a randomized trial: prolonged survival and possible reduced cancer rate, Arch Intern Med, 158, S1181, 10.1001/archinte.158.11.1181 · DOI · Paper page
  45. Flynn, 2004, Successful long-term weight loss with a Mediterranean style diet in a primary care medical center, Asia Pac J Clin Nutr, 13, S139
  46. Fernandez, 2003, A reduction in dietary saturated fat decreases body fat content in overweight, hypercholesterolemic males, Nutr Metab Cardiovasc Dis, 13, S273, 10.1016/S0939-4753(03)80031-5 · DOI
  47. Hyyppa, 2003, Does simvastatin affect mood and steroid hormone levels in hypercholesterolemic men? A randomized double-blind trial, Psychoneuroendocrinology, 28, S181, 10.1016/S0306-4530(02)00014-8 · DOI
  48. Wardle, 2000, Randomized trial of the effects of cholesterol-lowering dietary treatment on psychological function, Am J Med, 108, S547, 10.1016/S0002-9343(00)00330-2 · DOI
  49. Simopoulos, 2002, The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence, J Nutr, 13, S3065S
  50. Simopoulos, 2004, The traditional diet of Greece and cancer, Eur J Cancer Prev, 13, S219, 10.1097/01.cej.0000130011.99148.07 · DOI
  51. Ferro-Luzzi, 2002, The high-fat Greek diet: a recipe for all, Eur J Clin Nutr, 56, S796, 10.1038/sj.ejcn.1601393 · DOI
  52. Trichopoulos, 2002, In defense of the Mediterranean diet: a letter to the editor, Eur J Clin Nutr, 56, S928, 10.1038/sj.ejcn.1601521 · DOI
  53. Ferro-Luzzi, 2002, Response to the letter submitted by D Trichopoulos entitled ‘In defense of the Mediterranean diet, Eur J Clin Nutr, 56, S928, 10.1038/sj.ejcn.1601579 · DOI
  54. Serra-Majem, 1997, Nutrition policies in Mediterranean Europe, Nutr Rev, 55, S42
  55. Castagnetta, 2002, The Mediet project, Ann N Y Acad Sci, 963, S282, 10.1111/j.1749-6632.2002.tb04119.x · DOI
  56. Trichopoulou, 2003, Adherence to Mediterranean diet and survival in a Greek population, N Engl J Med, 348, S2599, 10.1056/NEJMoa025039 · DOI · Paper page
  57. Miro-Casas, 2001, Cappillary gas chromatography-mass spectrometry quantitative determination of hydrosytyrosol and tyrosol in human urine after olive oil intake, Analytical Biochem, 294, S63, 10.1006/abio.2001.5160 · DOI
  58. Bondia-Pons, 2004, Comparison of conventional and fast gas chromatography in human plasma fatty acid determination, J Chromatography, 809, S339
  59. Martinez-Gonzalez, 2004, Mediterranean diet, antioxidants and cancer: the need for randomized trials, Eur J Cancer Prev, 13, S327, 10.1097/01.cej.0000137512.71845.bf · DOI

Cited by

See all 527

Metadata

Authors
Serra-Majem, L., Roman, B., & Estruch, R.
Venue
Nutrition Reviews
Publisher
Oxford University Press (OUP)
Published
2006-02
Volume
64
Issue
2 Pt 2
Pages
S27-S47
ISSN
  • 0029-6643 (ISSN-L)
  • 1753-4887
DOI
10.1111/j.1753-4887.2006.tb00232.x
OpenAlex
W2098665066
Cited by
527
References
6
FWCI
4.97
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.