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Cited by 145

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

A prospective study of acute drug‐induced liver injury in patients suffering from non‐alcoholic fatty liver disease

Tarantino, Giovanni, Conca, Paolo, Basile, Vincenzo, Gentile, Antonio, Capone, Domenico, Polichetti, Giuliano, Leo, Emilio·2007·Hepatology Research
DOI 10.1111/j.1872-034x.2007.00072.x
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Abstract

Aim: Liver damage due to facultative hepatotoxins is scarcely foreseeable. We evaluated the prevalence of acute drug‐induced liver injury (DILI) in a specific setting, assessing eventual interactions with pre‐existing hepatic illnesses. Methods: The research was carried out in an Italian tertiary care hospital, by analyzing 248 patients with non‐advanced liver disease, divided into two well‐matched groups: 174 patients (median age 53, 94 females) with hepatitis C virus‐related chronic hepatitis; and 74 (median age 55, 39 females) with non‐alcoholic fatty liver disease (NAFLD). Results: Six patients (2.4% of the whole population) belonging to the NAFLD group (χ2‐test, P = 0.004) suffered from acute hepatoxicity related to the following drugs, that is antihypertensive, acting on platelet aggregation, antimicrobial, non‐steroidal anti‐inflammatory and proton pump inhibitor. The NAFLD presence was an independent risk factor in determining drug‐related acute hepatitis, with an odds ratio of 3.95 (95% confidence intervals: 11.48–1.35). Central obesity was relevant in every patient with acute toxicity. Alcohol consumption and drug association did not influence the acute drug‐induced liver damage. Conclusion: NAFLD conveys a nearly fourfold increase of DILI risk in obese middle‐aged patients. NAFLD, characterized by mitochondrial dysfunction, could predispose to drug‐induced hepatotoxicity that probably shares the same pathophysiological mechanism.

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Crossref · 10.1111/j.1872-034x.2007.00072.x

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2 of 2 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 25

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  14. 10.1097/01.pec.0000173350.45648.9b · DOI
  15. 10.1002/(SICI)1099-1557(199808)7:1 <S41::AID-PDS347>3.0.CO;2-2 · DOI
  16. 10.1002/hep.510270121 · DOI
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  19. Ong MM, 2006, Troglitazone‐induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities., Toxicol Sci, 00, 000
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  21. 10.2174/1389200043335531 · DOI
  22. 10.1080/01926230590522121 · DOI
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  24. 10.1023/A:1007649815992 · DOI
  25. 10.1097/00000542-198208000-00005 · DOI

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Metadata

Authors
Tarantino, G., Conca, P., Basile, V., Gentile, A., Capone, D., Polichetti, G., & Leo, E.
Venue
Hepatology Research
Publisher
Wiley
Published
2007-05-26
Volume
37
Issue
6
Pages
410-415
ISSN
  • 1386-6346
  • 1872-034X
DOI
10.1111/j.1872-034x.2007.00072.x
Cited by
145
References
2
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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