The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Alkaline phosphatase: beyond the liver
Abstract
Abstract The alkaline phosphatases comprise a heterogeneous group of enzymes that are widely distributed in mammalian cells. They often are associated with cell membranes, but their exact physiologic function is unknown. Despite this, alkaline phosphatase activity is a very useful serum biochemical indicator of liver disease, particularly cholestatic disease. However, increases in the activity of alkaline phosphatase in serum and other body fluids may reflect physiologic or pathologic changes beyond those of hepatic origin. For example, nonhepatic increases in serum alkaline phosphatase activity are found in young animals, in pregnant and lactating females, and in association with high fat diets. Bone disease, endocrine disease, neoplasia, and other disorders can result in increased alkaline phosphatase activity. In addition, alkaline phosphatase activity may be increased due to induction by certain drugs such as glucocorticoids and anticonvulsants. In this article, we will review the physiologic and pathologic factors influencing the activity of alkaline phosphatase in serum and other body fluids, with an emphasis on disorders beyond liver disease.
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Cites
Clinical Biochemistry of Domestic Animals
(1970) · Elsevier eBooks · doi:10.1016/c2013-0-10928-2 · Cited by 3,699
Schalm's Veterinary Hematology
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Tietz Textbook of Clinical Chemistry and Molecular Diagnostics
Burtis, E. B. C. A., Ashwood, E. R., & Bruns, D. E. (2011) · Medical Entomology and Zoology · Cited by 2,190
Canine and Feline Endocrinology and Reproduction
Peterson, M. E. (1988) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1988.tb02815.x · Cited by 1,391
Canine and Feline Endocrinology and Reproduction
Feldman, E. C., & Nelson, R. W. (1987) · Cited by 891
The human alkaline phosphatases: What we know and what we don't know
Harris, H. (1990) · Clinica Chimica Acta · doi:10.1016/0009-8981(90)90031-m · Cited by 505
Fundamentals of Veterinary Clinical Pathology
Stockham, S. L., & Scott, M. A. (2019) · Cited by 429
Changes in the blood biochemical and haematological profile of neonatal calves with age
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Fundamentals of Veterinary Clinical Pathology
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Hypothyroidism in dogs: 66 cases (1987-1992)
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Cai, Q., Huang, D., Yu, H., Zhu, Z., Xia, Z., Su, Y., Li, Z., Zhou, G., Gou, J., Qu, J., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.04.006 · Cited by 1,047
Xi, C.-Y., Zhang, M., Jiang, L., Chen, H.-Y., Lv, J., He, Y., Hafez, M. E., Qian, R.-C., & Li, D.-W. (2022) · Sensors and Actuators B: Chemical · doi:10.1016/j.snb.2022.132264 · Cited by 42
Metadata
- Authors
- Fernandez, & Kidney, B. A.
- Venue
- Veterinary Clinical Pathology
- Publisher
- Wiley
- Published
- 2007-09
- Volume
- 36
- Issue
- 3
- Pages
- 223-233
- ISSN
- 0275-6382 (ISSN-L)
- 1939-165X
- OpenAlex
- W2002487999
- Cited by
- 269
- References
- 39
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- closed
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