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The Effect of Levothyroxine Treatment on Resting Energy Expenditure of Hypothyroid Dogs
Open accessAbstract
Abstarct: Thirty adult, client-owned dogs were diagnosed with hypothyroidism based on history, physical examination findings, hematologic and biochemical abnormalities, thyrotropin (TSH) response testing, endogenous canine thyrotropin (cTSH) concentration, or both, and total serum thryoxine concentration. All dogs received levothyroxine (L-thyroxine) at an initial dose of 22 μg/kg PO sid in either a tablet (13 dogs) or chewable form (17 dogs). Energy expenditure of each dog during apparent rest was estimated with an open-flow indirect calorimetry system by determining the rates of carbon dioxide production and oxygen consumption. Energy expenditure of apparent rest (EE) was lower in untreated hypothyroid dogs compared with reference values for EE. After treatment with L-thyroxine, EE of the hypothyroid dogs was significantly (P < .05) higher than pretreatment values.
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Obesity comorbidities include osteoarthritis and endocrine diseases such as hypothyroidism, diabetes mellitus, and hyperadrenocorticism.
“Obesity comorbidities include osteoarthritis and endocrine diseases (e.g., hypothyroidism, diabetes mellitus, hyperadrenocorticism).37–40”
From 2021 AAHA Nutrition and Weight Management Guidelines for Dogs and Cats (2021) · cites this paper as [38]
In some cases, such as feline diabetes mellitus, preventing obesity may help reduce risk of developing the comorbidity; in others, such as hypothyroidism, the underlying condition continues to predispose to obesity unless managed.
“In some cases (e.g., feline diabetes mellitus), preventing obesity may help reduce the risk of developing the comorbidity, whereas in others (e.g., hypothyroidism), the underlying condition will continue to predispose to obesity development unless adequately managed.”
From 2021 AAHA Nutrition and Weight Management Guidelines for Dogs and Cats (2021) · cites this paper as [38]
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One-step N2-dilution technique for calibrating open-circuit VO2 measuring systems
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2021 AAHA Nutrition and Weight Management Guidelines for Dogs and Cats
Cline, M. G., Burns, K. M., Coe, J. B., Downing, R., Durzi, T., Murphy, M., & Parker, V. (2021) · Journal of the American Animal Hospital Association · doi:10.5326/jaaha-ms-7232 · Cited by 107
Metadata
- Authors
- Greco, D. S., Rosychuk, R. A. W., Ogilvie, G. K., Harpold, L. M., & Van Liew, C. H.
- Affiliations
- Colorado State University (US)
- College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO
- Corresponding author
- Greco, Deborah S.
- Venue
- Journal of Veterinary Internal Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-01-01
- Volume
- 12
- Issue
- 1
- Pages
- 7-10
- ISSN
- 0891-6640 (ISSN-L)
- 1939-1676
- OpenAlex
- W2045748940
- Cited by
- 28
- References
- 2
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2012: 1
- FWCI
- 1.49
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Journal of Veterinary Internal Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- canine hypothyroidism, levothyroxine, resting energy expenditure, thyroid hormone replacement, indirect calorimetry, CO2 emissions, oxygen consumption, dogs
- MeSH terms
- Animals, Basal Metabolism, Calorimetry, Indirect, Dog Diseases, Dogs, Female, Hypothyroidism, Male, Oxygen Consumption, Tablets, Thyroxine
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