Optimal reference interval for homeostasis model assessment of insulin resistance in a Japanese population: HOMA-IR reference interval in Japanese
Open accessAbstract
The aim of the present study was to establish a reference interval for homeostasis model assessment of insulin resistance (HOMA-IR) in a Japanese population based on the C28-A3 document from the Clinical and Laboratory Standards Institute (CLSI). We selected healthy subjects aged 20-79 years, with fasting plasma glucose < 100 mg/dL, body mass index < 25 kg/m(2) and alanine aminotransferase < 31 U/L. HOMA-IR values were log transformed, values beyond mean ± 3 standard deviations (SD) were truncated, and the mean ± 2 SD of log HOMA-IR values were taken as the upper and lower reference limits of HOMA-IR. We selected 2173 subjects as reference individuals, and 2153 subjects were used for analysis. The reference interval for HOMA-IR was established as between 0.4 and 2.4. This represents the first reference interval study for HOMA-IR that applies the stringent CLSI C28-A3 document. HOMA-IR ≥ 2.5 should be considered a reasonable indicator of insulin resistance in Japanese. (J Diabetes Invest, doi: 10.1111/j.2040-1124.2011.00113.x, 2011).
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There are ethnic differences in HOMA-IR cut-offs and gender variations.
“Moreover, there are both ethnic differences in cut-offs and gender variations [3,13].”
From Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population (2019) · cites this paper as [3]
The Discussion reports different HOMA-IR thresholds in Japanese and non-Asian studies and suggests ethnicity might contribute, but cautions that the studies cannot be directly compared without standardized methods. Table 1 in the Results gives slightly different mean HOMA-IR values for men and women; it does not establish gender-specific cut-offs. (LLM, conf=0.85)
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Cites
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Horáková, D., Štěpánek, L., Janout, V., Janoutová, J., Pastucha, D., Kollárová, H., Petráková, A., Štěpánek, L., Husár, R., & Martiník, K. (2019) · Medicina · doi:10.3390/medicina55050158 · Cited by 87 · see citing works
“Moreover, there are both ethnic differences in cut-offs and gender variations [3,13].”
Background
- Authors
- Yamada, C., Mitsuhashi, T., Hiratsuka, N., Inabe, F., Araida, N., & Takahashi, E.
- Affiliations
- Tokai University (JP)
- Corresponding author
- Takahashi, Eiko
- Venue
- Journal of Diabetes Investigation
- Publisher
- Wiley
- Published
- 2011-04-03
- Volume
- 2
- Issue
- 5
- Pages
- 373-376
- ISSN
- 2040-1116 (ISSN-L)
- PMC
- PMC4019305
- OpenAlex
- W1504450548
- Cited by
- 117
- References
- 3
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 6 · 2023: 7 · 2022: 17 · 2021: 10 · 2020: 7 · 2019: 12 · 2018: 10 · 2017: 6 · 2016: 4 · 2015: 7 · 2014: 1 · 2013: 2 · 2012: 3
- FWCI
- 1.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Diabetes Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Japan Society for the Promotion of Science (22653079)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- HOMA-IR, insulin resistance, reference values, Japanese population, fasting blood glucose, healthy adults, diagnostic thresholds
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