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The preparation and properties of niosomes—non-ionic surfactant vesicles
Abstract
Vesicles were prepared on hydration of a mixture of a single or double alkyl-chain, non-ionic surfactant with cholesterol. These vesicles, or ‘niosomes’, are capable of entrapping and retaining water soluble solutes such as carboxyfluorescein, are osmotically active and can be formulated to release entrapped solute slowly. The physical characteristics of the vesicles were found to be dependent on the method of production and three such methods, based on liposome technology, are described. The vesicles have been characterized by photon correlation spectroscopy, freeze fracture electron micrography, measurement of solute entrapment efficiency, and solute release rates. Vesicular forms of the single chain surfactant which could be formed under certain conditions in the absence of cholesterol are also described.
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Citations
Cites
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664
Cited by
Non-ionic surfactant based vesicles (niosomes) in drug delivery
Uchegbu, I. F., & Vyas, S. P. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00169-0 · Cited by 1,020
Studies on a high encapsulation of colchicine by a niosome system
Hao, Y., Zhao, F., Li, N., Yang, Y., & Li, K. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00301-0 · Cited by 365
A Comprehensive Review on Niosomes as a Tool for Advanced Drug Delivery
Sharma, S., Garg, A., Agrawal, R., Chopra, H., & Pathak, D. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/2211738511666230726154557 · Cited by 25
Metadata
- Authors
- Baillie, A. J., Florence, A. T., Hume, L. R., Muirhead, G. T., & Rogerson, A.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-12-01
- Volume
- 37
- Issue
- 12
- Pages
- 863-868
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2119364806
- Cited by
- 473
- References
- 1
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baillie, A. J., Florence, A. T., Hume, L. R., Muirhead, G. T., & Rogerson, A. (1985). The preparation and properties of niosomes—non-ionic surfactant vesicles. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1985.tb04990.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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