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The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice
Abstract
Non-ionic surfactant vesicles (niosomes) prepared from a non-ionic surfactant, cholesterol and dicetyl phosphate and containing methotrexate (MTX) have been administered to mice. Given intravenously the niosomes prolong the levels of MTX in the blood, large amounts of the drug being taken up by the liver. There was also an increased uptake of MTX into the brain, perhaps due to an effect of the niosome components on the permeability of the blood brain barrier. Absorption of the drug from the gastrointestinal tract following oral ingestion, appeared to be increased at some doses; most of the entrapped MTX was taken up by the liver, but uptake of MTX into the brain was also increased. The metabolic profile of the drug is altered by the niosomes which appear to prevent the rapid formation of 7-hydroxy methotrexate.
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Cited by
Non-ionic surfactant based vesicles (niosomes) in drug delivery
Uchegbu, I. F., & Vyas, S. P. (1998) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(98)00169-0 · Cited by 1,020
Potential of solid lipid nanoparticles in brain targeting.
Kaur, I. P., Bhandari, R., Bhandari, S., & Kakkar, V. (2008) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.12.018 · Cited by 615
Studies on a high encapsulation of colchicine by a niosome system
Hao, Y., Zhao, F., Li, N., Yang, Y., & Li, K. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00301-0 · Cited by 365
A Comprehensive Review on Niosomes as a Tool for Advanced Drug Delivery
Sharma, S., Garg, A., Agrawal, R., Chopra, H., & Pathak, D. (2024) · Pharmaceutical Nanotechnology · doi:10.2174/2211738511666230726154557 · Cited by 25
Metadata
- Authors
- Azmin, M. N., Florence, A. T., Handjani-Vila, R. M., Stuart, J. F. B., Vanlerberghe, G., & Whittaker, J. S.
- Venue
- Journal of Pharmacy and Pharmacology
- Publisher
- Oxford University Press (OUP)
- Published
- 1985-04-01
- Volume
- 37
- Issue
- 4
- Pages
- 237-242
- ISSN
- 0022-3573 (ISSN-L)
- 2042-7158
- OpenAlex
- W2014219230
- Cited by
- 321
- References
- 0
- FWCI
- 7.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. https://app.cochat.ai/papers/10.1111/j.2042-7158.1985.tb05051.x
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- Azmin, M. N., Florence, A. T., Handjani-Vila, R. M., Stuart, J. F. B., Vanlerberghe, G., & Whittaker, J. S. (1985). The effect of non-ionic surfactant vesicle (niosome) entrapment on the absorption and distribution of methotrexate in mice. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.1985.tb05051.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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