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Cited by 405

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods

Open access
Peltonen, Leena, Hirvonen, Jouni·2010·Journal of Pharmacy and Pharmacology
DOI 10.1111/j.2042-7158.2010.01022.x
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Abstract

Objectives: Wet milling is a common technique to produce drug nanocrystals. Stability of the nanocrystals is a critical question, and different kinds of stabilizers, e.g. polymers, celluloses, surfactants and lipids, have been tested for various drugs. Still, the question about how to select the best stabilizer to a certain drug material and also to a selected process is open. Key findings: Many different factors, such as surface energy, hydrophobicity, solubility, viscosity and functional groups, affect the stability of the formed nanosuspensions. Affinity of the stabilizer to the particle surfaces seems to be the most important parameter. This affinity is partly related to the surface energy and hydrophobicity of the surfaces and stabilizers. Summary: In this review the most important factors affecting nanocrystal formulation and efficacy of stabilizers are presented. In order to widen understanding of the milling process, the most important variables related to milling techniques and particle fracturing processes during the milling are briefly presented.

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Metadata

Authors
Peltonen, L., & Hirvonen, J.
Venue
Journal of Pharmacy and Pharmacology
Publisher
Oxford University Press (OUP)
Published
2010-11-01
Volume
62
Issue
11
Pages
1569-1579
ISSN
  • 0022-3573 (ISSN-L)
  • 2042-7158
DOI
10.1111/j.2042-7158.2010.01022.x
OpenAlex
W1853947313
Cited by
405
References
46
FWCI
10.07
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods. https://app.cochat.ai/papers/10.1111/j.2042-7158.2010.01022.x
The paper
Peltonen, L., & Hirvonen, J. (2010). Pharmaceutical nanocrystals by nanomilling: critical process parameters, particle fracturing and stabilization methods. Journal of Pharmacy and Pharmacology. https://doi.org/10.1111/j.2042-7158.2010.01022.x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.