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Quantal Responses to Mixtures of Poisons
Abstract
Summary: Various models for the joint action of poisons are examined. An attempt is made to clarify the differences between similar and dissimilar physiological actions; in similar action, the poisons act at a common site, whereas in dissimilar action each acts at a different site. In order to allow for the influence of one poison upon the action of another, the concept of interaction is defined on a physiological basis. Relations between mortality and dose are constructed for each model, and methods of estimation and tests of significance are put forward. These are illustrated by data from insecticidal experiments. The set of models considered is by no means exhaustive, and it may sometimes be found that others are required to give a satisfactory description of comparable data.
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Citations
Cited by
Backhaus, T., Altenburger, R., Boedeker, W., Faust, M., Scholze, M., & Grimme, L. H. (2000) · Environmental Toxicology and Chemistry · doi:10.1002/etc.5620190927 · Cited by 391
Anion effects on the cytotoxicity of ionic liquids
Stolte, S., Arning, J., Bottin-Weber, U., Matzke, M., Stock, F., Thiele, K., Uerdingen, M., Welz-Biermann, U., Jastorff, B., & Ranke, J. (2006) · Green Chemistry · doi:10.1039/b602161a · Cited by 338
A REDUCTION FORMULA FOR NORMAL MULTIVARIATE INTEGRALS
PLACKETT, R. L. (1954) · Biometrika · doi:10.1093/biomet/41.3-4.351 · Cited by 273
Self-citationA reduction formula for normal multivariate integrals
Plackett, R. L. (1954) · Biometrika · doi:10.2307/2332716 · Cited by 262
Self-citationInteraction Index and Different Methods for Determining Drug Interaction in Combination Therapy
Lee, J. J., Kong, M., Ayers, G. D., & Lotan, R. (2007) · Journal of Biopharmaceutical Statistics · doi:10.1080/10543400701199593 · Cited by 135
Metadata
- Authors
- Plackett, R. L., & Hewlett, P. S.
- Venue
- Journal of the Royal Statistical Society Series B: Statistical Methodology
- Publisher
- Oxford University Press (OUP)
- Published
- 1952-07-01
- Volume
- 14
- Issue
- 2
- Pages
- 141-154
- ISSN
- 1369-7412 (ISSN-L)
- 1467-9868
- OpenAlex
- W2903719645
- Cited by
- 206
- References
- 0
- FWCI
- 7.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- Plackett, R. L., & Hewlett, P. S. (1952). Quantal Responses to Mixtures of Poisons. Journal of the Royal Statistical Society Series B: Statistical Methodology. https://doi.org/10.1111/j.2517-6161.1952.tb00108.x
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