New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis

Han, Chenyang; Yang, Yi; Guan, Qiaobing; Zhang, Xiaoling; Shen, Heping; Sheng, Yongjia; Wang, Jin; Zhou, Xiaohong; Li, Wenyan; Guo, Li; Jiao, Qingcai

doi:10.1111/jcmm.15439

New mechanism of nerve injury in Alzheimer’s disease: β‐amyloid‐induced neuronal pyroptosis

The present study was designed to investigate the role of β‐amyloid (Aβ 1‐42 ) in inducing neuronal pyroptosis and its mechanism. Mice cortical neurons (MCNs) were used in this study, LPS + Nigericin was used to induce pyroptosis in MCNs (positive control group), and Aβ 1‐42 was used to interfere…