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Cited by 55Mitochondrial Function and PathologyIon Channels and ReceptorsAutophagy in Disease and Therapy

Mitochondria‐associated endoplasmic reticulum membrane: Overview and inextricable link with cancer

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Yang, Xi, Zhuang, Jing, Song, Weilong, Shen, Wangjie, Wu, Wei, Shen, Hong, Han, Shuwen·2023·Journal of Cellular and Molecular Medicine
DOI 10.1111/jcmm.17696PMC PMC10064038
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Abstract

The mitochondrial‐associated membrane (MAM) is a physical platform that facilitates communication between the endoplasmic reticulum (ER) and mitochondria. It is enriched with many proteins and enzymes and plays an important role in the regulation of several fundamental physiological processes, such as calcium (Ca 2+) transfer, lipid synthesis, cellular autophagy and ER stress. Accumulating evidence suggests that oncogenes and suppressor genes are present at the ER‐mitochondrial contact site, and their alterations can affect Ca 2+ flux, lipid homeostasis, and the dysregulation of mitochondrial dynamics, thereby influencing the fate of cancer cells. Understanding the fundamental role of MAM‐resident proteins in tumorigenesis could support the search for novel therapeutic targets in cancer. In this review, we summarize the basic structure of MAM and the core functions of MAM‐resident proteins in tumorigenesis. In addition, we discuss the mechanisms by which natural compounds promote cancer cell apoptosis from the perspective of ER stress.

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  • MAMs are hubs for lipid and cholesterol metabolism, Ca2+ transfer, autophagy initiation, and mitochondrial fission.

    “A growing body of work highlights the importance of mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) as hubs for lipid and cholesterol metabolism, Ca2+ transfer, autophagy initiation, and mitochondrial fission [56].”

    From Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses (2026) · cites this paper as [56]

    The Introduction and Conclusion describe MAMs as hubs involved in lipid metabolism, Ca2+ transfer, and autophagy. The lipid-metabolism section specifically discusses cholesterol-related proteins, and the autophagy section describes events at MAMs during autophagy initiation. The copy mentions mitochondrial membrane dynamics but does not specifically identify MAMs as hubs for mitochondrial fission; no page numbers were provided. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The MAM hypothesis suggests defective inter-organelle signaling, rather than amyloid aggregation alone, may be a central driver of AD pathophysiology.

    “This “MAM hypothesis” suggests that defective inter-organelle signaling, rather than amyloid aggregation alone, may be a central driver of AD pathophysiology [56].”

    From Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses (2026) · cites this paper as [56]

    The Introduction describes MAM as an ER–mitochondrial signaling hub, while the Conclusion discusses its role in cancer. Searches for Alzheimer’s disease, amyloid, and defective inter-organelle signaling found no passage in the paper’s discussion that addresses the proposed explanation of AD pathophysiology; an Alzheimer’s-related work appears only in the references. (LLM, conf=0.76)

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Cited by

Sorted by citations

Authors
Yang, X., Zhuang, J., Song, W., Shen, W., Wu, W., Shen, H., & Han, S.
Affiliations
  • Huzhou Normal University (CN)
  • Huzhou Central Hospital, Affiliated Central Hospital Huzhou University Huzhou China
Corresponding author
  • Shen, Hong
  • Han, Shuwen
ORCID
Venue
Journal of Cellular and Molecular Medicine
Publisher
Wiley
Published
2023-02-27
Volume
27
Issue
7
Pages
906-919
ISSN
  • 1582-1838 (ISSN-L)
  • 1582-4934
DOI
10.1111/jcmm.17696
PMC
PMC10064038
OpenAlex
W4322617889
Cited by
55
References
4
Citations by year
2026: 14 · 2025: 18 · 2024: 15 · 2023: 8
FWCI
1.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Cellular and Molecular Medicine (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Natural Science Foundation of Zhejiang Province (Q23H160033)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords
mitochondria-associated endoplasmic reticulum membranes, ER-mitochondria contact sites, calcium transfer, lipid homeostasis, autophagy, endoplasmic reticulum stress, mitochondrial dynamics, oncogenes, tumor suppressor, carcinogenesis, tumor cell apoptosis, natural compounds, cancer therapy targets
MeSH terms
Calcium, Endoplasmic Reticulum, Humans, Lipids, Mitochondria, Neoplasms, Mitochondrial Membranes, Carcinogenesis

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