Cited by 264Oral microbiology and periodontitis researchDental Health and Care UtilizationPeriodontal Regeneration and Treatments

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Natural history of periodontitis: Disease progression and tooth loss over 40 years

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Ramseier, Christoph A., Anerud, Age, Dulac, Mary, Lulic, Martina, Cullinan, Mary P., Seymour, Gregory J., Faddy, Malcolm J., Bürgin, Walter, Schätzle, Marc, Lang, Niklaus P.·2017·Journal of Clinical Periodontology

DOI 10.1111/jcpe.12782

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Abstract

OBJECTIVES: To assess long-term attachment and periodontitis-related tooth loss (PTL) in untreated periodontal disease over 40 years. MATERIAL AND METHODS: Data originated from the natural history of periodontitis study in Sri Lankan tea labourers first examined in 1970. In 2010, 75 subjects (15.6%) of the original cohort were re-examined. RESULTS: PTL over 40 years varied between 0 and 28 teeth (mean 13.1). Four subjects presented with no PTL, while 12 were edentulous. Logistic regression revealed attachment loss as a statistically significant covariate for PTL (p < .004). Markov chain analysis showed that smoking and calculus were associated with disease initiation and that calculus, plaque, and gingivitis were associated with loss of attachment and progression to advanced disease. Mean attachment loss <1.81 mm at the age of 30 yielded highest sensitivity and specificity (0.71) to allocate subjects into a cohort with a dentition of at least 20 teeth at 60 years of age. CONCLUSIONS: These results highlight the importance of treating early periodontitis along with smoking cessation, in those under 30 years of age. They further show that calculus removal, plaque control, and the control of gingivitis are essential in preventing disease progression, further loss of attachment and ultimately tooth loss.

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Periodontal Disease in Pregnancy II. Correlation Between Oral Hygiene and Periodontal Condition
Silness, J., & Löe, H. (1964) · Acta Odontologica Scandinavica · doi:10.3109/00016356408993968 · Cited by 7,932
Periodontal Disease in Pregnancy I. Prevalence and Severity
Löe, H. A., & Silness, J. (1963) · Acta Odontologica Scandinavica · doi:10.3109/00016356309011240 · Cited by 7,234
The Gingival Index, the Plaque Index and the Retention Index Systems
Löe, H. (1967) · The Journal of Periodontology · doi:10.1902/jop.1967.38.6.610 · Cited by 4,247
Natural history of periodontal disease in man: Rapid, moderate and no loss of attachment in Sri Lankan laborers 14 to 46 years of age
Löe, H., Anerud, A., Boysen, H., & Morrison, E. (1986) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1986.tb01487.x · Cited by 839
Biting and Chewing in Overdentures, Full Dentures, and Natural Dentitions
Fontijn-Tekamp, F. A., Slagter, A. P., van der Bilt, A., Hof, M. A. V. '., Witter, D. J., Kalk, W., & Jansen, J. A. (2000) · Journal of Dental Research · doi:10.1177/00220345000790071501 · Cited by 826
Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research
Tonetti, M. S., Claffey, N. M., & on behalf of the European Workshop in Periodontology group C (2005) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2005.00822.x · Cited by 617
The Natural History of Periodontal Disease in Man: Prevalence, Severity, and Extent of Gingival Recession
Löe, H. A., Ånerud, Å., & Boysen, H. (1992) · Journal of Periodontology · doi:10.1902/jop.1992.63.6.489 · Cited by 576
The Natural History of Periodontal Disease in Man: The Rate of Periodontal Destruction Before 40 Years of Age
Löe, H. A., Ånerud, Å., Boysen, H., & Smith, M. R. (1978) · Journal of Periodontology · doi:10.1902/jop.1978.49.12.607 · Cited by 471
Errors in the clinical assessment of periodontal destruction
Glavind, L., & Löe, H. A. (1967) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1967.tb01887.x · Cited by 397
The natural history of periodontal disease in man: Study design and baseline data
Löe, H., ÅNerud, Å., Boysen, H., & Smith, M. (1978) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.1978.tb00209.x · Cited by 250

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Harris K. (2010).ROC Hard? No ROC Made Easy. In:Proceedings of the SAS Global Forum 2010 Conference.Cary NC:SAS Institute Inc.

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Authors: Ramseier, C. A., Anerud, A., Dulac, M., Lulic, M., Cullinan, M. P., Seymour, G. J., Faddy, M. J., Bürgin, W., Schätzle, M., & Lang, N. P.
Affiliations: University of Bern (CH)
The University of Honk Kong Hong Kong China
University of Hong Kong (HK)
The University of Queensland (AU)
Queensland University of Technology (AU)
University of Zurich (CH)
Corresponding author: Lang, Niklaus P.
ORCID: Ramseier, Christoph A.
Cullinan, Mary P.
Seymour, Gregory J.
Faddy, Malcolm J.
Schätzle, Marc
Lang, Niklaus P.
Venue: Journal of Clinical Periodontology
Publisher: Wiley
Published: 2017-09-22
Volume: 44
Issue: 12
Pages: 1182-1191
ISSN: 0303-6979 (ISSN-L)
1600-051X
DOI: 10.1111/jcpe.12782
OpenAlex: W2738605185
Cited by: 264
References: 24
Citations by year: 2026: 13 · 2025: 43 · 2024: 46 · 2023: 39 · 2022: 34 · 2021: 36 · 2020: 27 · 2019: 17 · 2018: 7 · 2017: 2
FWCI: 20.00
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Journal Of Clinical Periodontology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
Bern Open Repository and Information System (University of Bern) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
Zurich Open Repository and Archive (University of Zurich)
Funders: Cancer Research Foundation
Society of Surgical Oncology
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
Keywords: periodontitis, tooth loss, attachment loss, disease progression, smoking, dental calculus, dental plaque, gingivitis, edentulism, Markov chain analysis
MeSH terms: Adolescent, Adult, Areca, Dental Calculus, Dental Plaque, Gingivitis, Habits, Hong Kong, Humans, Jaw, Edentulous, Partially, Longitudinal Studies, Male, Markov Chains, Mouth, Edentulous, Periodontal Diseases, Periodontal Index, Periodontitis, Risk Factors, Sensitivity and Specificity, Smoking, Time Factors, Logistic Models, Tooth Loss, Smoking Cessation, Periodontal Attachment Loss, Disease Progression, Chronic Periodontitis, Young Adult

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Natural history of periodontitis: Disease progression and tooth loss over 40 years

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