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ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients
Open accessAbstract
Atopic dermatitis (AD) is a clinically defined, highly pruritic, chronic inflammatory skin disease of children and adults. The diagnosis is made using evaluated clinical criteria. Disease activity is best measured with a composite score assessing both objective signs and subjective symptoms, such as SCORAD. The management of AD must consider the clinical and pathogenic variabilities of the disease and also target flare prevention. Basic therapy includes hydrating topical treatment, as well as avoidance of specific and unspecific provocation factors. Anti‐inflammatory treatment of visible skin lesions is based on topical glucocorticosteroids and the topical calcineurin inhibitors tacrolimus and pimecrolimus. Topical calcineurin inhibitors are preferred in sensitive locations. Tacrolimus and mid‐potent steroids are proven for proactive therapy, which is long‐term intermittent anti‐inflammatory therapy of the frequently relapsing skin areas. Systemic anti‐inflammatory or immunosuppressive treatment is indicated for severe refractory cases. Biologicals targeting key mechanisms of the atopic immune response are promising emerging treatment options. Microbial colonization and superinfection may induce disease exacerbation and can justify additional antimicrobial treatment. Systemic antihistamines (H1R‐blockers) may diminish pruritus, but do not have sufficient effect on lesions. Adjuvant therapy includes UV irradiation, preferably UVA 1 or narrow‐band UVB 311 nm. Dietary recommendations should be patient specific and elimination diets should only be advised in case of proven food allergy. Allergen‐specific immunotherapy to aeroallergens may be useful in selected cases. Psychosomatic counselling is recommended to address stress‐induced exacerbations. ‘Eczema school’ educational programmes have been proven to be helpful for children and adults.
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Johansson, S. G. O., Bieber, T., Dahl, R., Friedmann, P. S., Lanier, B. Q., Lockey, R. F., Motala, C., Ortega Martell, J. A., Platts-Mills, T. A. E., Ring, J., et al. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.12.591 · Cited by 2,391
Self-citationKong, H. H., Oh, J., Deming, C., Conlan, S., Grice, E. A., Beatson, M. A., Nomicos, E., Polley, E. C., Komarow, H. D., Program, N. C. S., et al. (2012) · Genome Research · doi:10.1101/gr.131029.111 · Cited by 1,808
Emollient enhancement of the skin barrier from birth offers effective atopic dermatitis prevention
Simpson, E. L., Chalmers, J. R., Hanifin, J. M., Thomas, K. S., Cork, M. J., McLean, W. H. I., Brown, S. J., Chen, Z., Chen, Y., & Williams, H. C. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.08.005 · Cited by 722
Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
van den Bogaard, E. H., Bergboer, J. G. M., Vonk-Bergers, M., van Vlijmen-Willems, I. M. J. J., Hato, S. V., van der Valk, P. G. M., Schröder, J. M., Joosten, I., Zeeuwen, P. L. J. M., & Schalkwijk, J. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65642 · Cited by 373
Oldhoff, J. M., Darsow, U., Werfel, T., Katzer, K., Wulf, A., Laifaoui, J., Hijnen, D. J., Plötz, S., Knol, E. F., Kapp, A., et al. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00791.x · Cited by 339
Self-citationSchmitt, J., von Kobyletzki, L., Svensson, Å., & Apfelbacher, C. (2011) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2010.10030.x · Cited by 257
Self-citationSafety of dermatologic medications in pregnancy and lactation
Murase, J. E., Heller, M. M., & Butler, D. C. (2014) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2013.09.010 · Cited by 220
Heil, P. M., Maurer, D., Klein, B., Hultsch, T., & Stingl, G. (2010) · JDDG: Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/j.1610-0387.2010.07497.x · Cited by 197
Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber
Werfel, T., Heratizadeh, A., Niebuhr, M., Kapp, A., Roesner, L. M., Karch, A., Erpenbeck, V. J., Lösche, C., Jung, T., Krug, N., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.04.015 · Cited by 171
Self-citationA Pilot Study of an Oral Phosphodiesterase Inhibitor (Apremilast) for Atopic Dermatitis in Adults
Samrao, A., Berry, T. M., Goreshi, R., & Simpson, E. L. (2012) · Archives of Dermatology · doi:10.1001/archdermatol.2012.812 · Cited by 166
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Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis
Simpson, E. L., Bieber, T., Guttman-Yassky, E., Beck, L. A., Blauvelt, A., Cork, M. J., Silverberg, J. I., Deleuran, M., Kataoka, Y., Lacour, J.-P., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1610020 · Cited by 2,110
Self-citationWeidinger, S., Beck, L. A., Bieber, T., Kabashima, K., & Irvine, A. D. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0001-z · Cited by 1,549
Wollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., Muraro, A., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14891 · Cited by 1,181
Self-citationWollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., Muraro, A., et al. (2018) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.14888 · Cited by 684
Self-citationAnti–Interleukin-31 Receptor A Antibody for Atopic Dermatitis
Ruzicka, T., Hanifin, J. M., Furue, M., Pulka, G., Mlynarczyk, I., Wollenberg, A., Galus, R., Etoh, T., Mihara, R., Yoshida, H., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1606490 · Cited by 592
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Metadata
- Authors
- Wollenberg, A., Oranje, A., Deleuran, M., Simon, D., Szalai, Z., Kunz, B., Svensson, A., Barbarot, S., von Kobyletzki, L., Taieb, A., de Bruin‐Weller, M., Werfel, T., Trzeciak, M., Vestergard, C., Ring, J., Darsow, U., & the European Task Force on Atopic Dermatitis/EADV Eczema Task Force
- Venue
- Journal of the European Academy of Dermatology and Venereology
- Publisher
- Wiley
- Published
- 2016-03-23
- Volume
- 30
- Issue
- 5
- Pages
- 729-747
- ISSN
- 0926-9959 (ISSN-L)
- 1468-3083
- OpenAlex
- W2306524933
- Cited by
- 395
- References
- 10
- FWCI
- 63.54
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. https://app.cochat.ai/papers/10.1111/jdv.13599
- The paper
- Wollenberg, A., Oranje, A., Deleuran, M., Simon, D., Szalai, Z., Kunz, B., Svensson, A., Barbarot, S., von Kobyletzki, L., Taieb, A., de Bruin‐Weller, M., Werfel, T., Trzeciak, M., Vestergard, C., Ring, J., Darsow, U., & the European Task Force on Atopic Dermatitis/EADV Eczema Task Force. (2016). ETFAD/EADV Eczema task force 2015 position paper on diagnosis and treatment of atopic dermatitis in adult and paediatric patients. Journal of the European Academy of Dermatology and Venereology. https://doi.org/10.1111/jdv.13599
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
