The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Microbial Eukaryotes that Lack Sterols
Abstract
It is widely held that sterols are key cyclic triterpenoid lipids in eukaryotic cell membranes and are synthesized through oxygen‐dependent multienzyme pathways. However, there are known exceptions―ciliated protozoans, such as Tetrahymena, along with diverse low‐oxygen‐adapted eukaryotes produce, instead of sterols, the cyclic triterpenoid lipid tetrahymanol that does not require molecular oxygen for its biosynthesis. Here, we report that a number of anaerobic microbial eukaryotes (protists) utilize neither sterols nor tetrahymanol in their membranes. The lack of detectable sterol‐like compounds in their membranes may provide an opportunity to reconsider the physiological function of sterols and sterol‐like lipids in eukaryotes.
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Early eukaryotes living under low O2 conditions may not have produced sterols.
“For example, early eukaryotes living under low O2 conditions may not have produced sterols (Takishita et al., 2017).”
From Oxygenation, Life, and the Planetary System during Earth's Middle History: An Overview (2021) · cites this paper as Takishita et al., 2017
Citations
Cites
Steroids, triterpenoids and molecular oxygen
Summons, R. E., Bradley, A. S., Jahnke, L. L., & Waldbauer, J. R. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1837 · Cited by 364
Reappraisal of hydrocarbon biomarkers in Archean rocks
French, K. L., Hallmann, C., Hope, J. M., Schoon, P. L., Zumberge, J. A., Hoshino, Y., Peters, C. A., George, S. C., Love, G. D., Brocks, J. J., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1419563112 · Cited by 307
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Sorted by citations
Oxygenation, Life, and the Planetary System during Earth's Middle History: An Overview
Lyons, T. W., Diamond, C. W., Planavsky, N. J., Reinhard, C. T., & Li, C. (2021) · Astrobiology · doi:10.1089/ast.2020.2418 · Cited by 211
“For example, early eukaryotes living under low O2 conditions may not have produced sterols (Takishita et al., 2017).”
Background
Metadata
- Authors
- Takishita, K., Chikaraishi, Y., Tanifuji, G., Ohkouchi, N., Hashimoto, T., Fujikura, K., & Roger, A. J.
- Affiliations
- Japan Agency for Marine-Earth Science and Technology (JP)
- National Museum of Nature and Science (JP)
- University of Tsukuba (JP)
- Dalhousie University (CA)
- Corresponding author
- Takishita, Kiyotaka
- ORCID
- Venue
- Journal of Eukaryotic Microbiology
- Publisher
- Wiley
- Published
- 2017-06-07
- Volume
- 64
- Issue
- 6
- Pages
- 897-900
- ISSN
- 1066-5234 (ISSN-L)
- 1550-7408
- OpenAlex
- W2616601599
- Cited by
- 24
- References
- 2
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 1
- FWCI
- 0.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Eukaryotic Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science London (15K07176, 15H05231)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Keywords
- sterol biosynthesis, tetrahymanol, membrane lipids, anaerobic protists, ciliates, Tetrahymena
- MeSH terms
- Cell Membrane, Sterols, Triterpenes, Eukaryota
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