Effects of coeliacomesenteric blood flow reduction on intestinal barrier function in rainbow trout Oncorhynchus mykiss
Abstract
The aim of the current work was to elucidate if there is a connection between stress‐induced decrease in coeliacomesenteric artery blood flow (i.e. gastrointestinal blood flow; GBF) and disruption of the intestinal primary barrier in rainbow trout Oncorhynchus mykiss. Upon initiation of a 15 min acute chasing stress, the GBF decreased instantly by c. 92%. The GBF then slowly increased and reached c. 28% of resting values at the end of the stress protocol. After the stress was ceased, the GBF slowly increased and returned to resting values within c. 45 min. Intestinal permeability assessment in an Ussing‐chambers set‐up revealed impaired intestinal barrier function 24 h after stress. When the stress‐induced GBF reduction was mimicked by an experimental occlusion of the coeliacomesenteric artery for 15 min followed by 24 h recovery, no effect on intestinal barrier function was observed. These results suggest that no direct causal relationship can be found between the GBF reduction and development of intestinal barrier dysfunction following periods of acute stress in this species of fish.
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Gut barrier function can be decreased through increased ionic and physical leakiness of the gastrointestinal tract.
“As part of the secondary stress response, the gut barrier function can be decreased through increased ionic and physical “leakiness” of the gastrointestinal tract (Sundh et al., 2010; Sundh et al., 2018).”
From Insights into thermal sensitivity: Effects of elevated temperature on growth, metabolic rate, and stress responses in Atlantic wolffish (<i>Anarhichas lupus</i>) (2025) · cites this paper as Sundh et al., 2018
Impaired barrier function can be induced in fish by several husbandry-related practices, including acute handling stress, poor water quality, and chronic feed stress.
“Impaired barrier function can be induced in fish by several different husbandry‐related practices, including acute handling stress (Olsen et al., 2005, 2008; Sundh et al., 2018), poor water quality (Sundh et al., 2009; Sundh et al., 2010; Sundh et al., 2019), and chronic feed stress (Estensoro et al., 2016; Knudsen et al., 2008; Venkatakrishnan et al., 2019; Vidakovic et al., 2016).”
From Insights into thermal sensitivity: Effects of elevated temperature on growth, metabolic rate, and stress responses in Atlantic wolffish (<i>Anarhichas lupus</i>) (2025) · cites this paper as Sundh et al., 2018
Cites
Exercise-Induced Splanchnic Hypoperfusion Results in Gut Dysfunction in Healthy Men
van Wijck, K., Lenaerts, K., van Loon, L. J. C., Peters, W. H. M., Buurman, W. A., & Dejong, C. H. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022366 · Cited by 359 · see citing works
Sundh, H., Kvamme, B., Fridell, F., Olsen, R., Ellis, T., Taranger, G., & Sundell, K. (2010) · BMC Physiology · doi:10.1186/1472-6793-10-22 · Cited by 104 · see citing works
Self-citationGastrointestinal profile of symptomatic athletes at rest and during physical exercise
van Nieuwenhoven, M. A., Brouns, F., & Brummer, R.-J. M. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-003-1007-z · Cited by 103 · see citing works
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Hinchcliffe, J., Roques, J. A. C., Ekström, A., Hedén, I., Sundell, K., Sundh, H., Sandblom, E., Björnsson, B. T., & Jönsson, E. (2025) · Journal of Fish Biology · doi:10.1111/jfb.16017 · Cited by 11 · see citing works
Self-citation
- Authors
- Sundh, H., Gräns, A., Brijs, J., Sandblom, E., Axelsson, M., Berg, C., & Sundell, K.
- Affiliations
- University of Gothenburg (SE)
- Swedish University of Agricultural Sciences (SE)
- Corresponding author
- Sundh, Henrik
- ORCID
- Venue
- Journal of Fish Biology
- Publisher
- Wiley
- Published
- 2018-09
- Volume
- 93
- Issue
- 3
- Pages
- 519-527
- ISSN
- 0022-1112 (ISSN-L)
- 1095-8649
- OpenAlex
- W2811085882
- Cited by
- 10
- References
- 3
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2021: 1 · 2019: 2 · 2018: 2
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Fish Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Svenska Forskningsrådet Formas (223‐2013‐297)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Keywords
- gastrointestinal blood flow, intestinal barrier function, intestinal permeability, acute stress, rainbow trout, intestinal ischemia
- MeSH terms
- Animals, Intestinal Mucosa, Permeability, Splanchnic Circulation, Stress, Psychological, Oncorhynchus mykiss, Gastrointestinal Tract
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