Oxidative and nitrative alpha‐synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies

Schildknecht, Stefan, Gerding, Hanne R., Karreman, Christiaan, Drescher, Malte, Lashuel, Hilal A., Outeiro, Tiago F., Di Monte, Donato A., Leist, Marcel·2013·Journal of Neurochemistry

Cites (240)

Items 201–238 of 238

  1. Cellular Oligomerization of α-Synuclein Is Determined by the Interaction of Oxidized Catechols with a C-terminal Sequence
    Joseph R. Mazzulli, Maria Armakola, Michelle Bridi, Ioannis Parastatidis, Harry Ischiropoulos · 2007 · Journal of Biological Chemistry
  2. Inter-Helix Distances in Lysophospholipid Micelle-Bound α-Synuclein from Pulsed ESR Measurements
    Peter P. Borbat, Trudy F. Ramlall, Jack H. Freed, David Eliezer · 2006 · Journal of the American Chemical Society
  3. Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates
    Alexander S. Maltsev, Jue Chen, Rodney L. Levine, Ad Bax · 2013 · Journal of the American Chemical Society
  4. Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys
    Alison L. McCormack, Sally K. Mak, Maryam Shenasa, J. William Langston, Lysia S. Forno, Donato A. Di Monte · 2008 · Journal of Neuropathology & Experimental Neurology
  5. Beyond α-synuclein transfer: pathology propagation in Parkinson's disease
    Christian Hansen, Jiayi Li · 2012 · Trends in Molecular Medicine
  6. Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
    Alison L. McCormack, Sally K. Mak, Donato A. Di Monte · 2012 · Cell Death and Disease
  7. Redox regulation: A new challenge for pharmacology
    Daniel Frein, Stefan Schildknecht, Markus Michael Bachschmid, Volker Ullrich · 2005 · Biochemical Pharmacology
  8. Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells
    Thomas Näsström, Susana A. Gonçalves, Charlotte Sahlin, Eva K. L. Nordström, Valentina Screpanti Sundquist, Lars Lannfelt, Joakim J. E. Bergström, Tiago F. Outeiro, Martin Ingelsson · 2011 · PLoS ONE
  9. Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane‐Bound Alpha‐Synuclein
    Marta Robotta, Patrick Braun, Bart D. van Rooijen, Vinod Subramaniam, Martina Huber, Malte Drescher · 2010 · ChemPhysChem
  10. The Effect of Truncated Human α-Synuclein (1–120) on Dopaminergic Cells in a Transgenic Mouse Model of Parkinson's Disease
    Andrew W. Michell, George K. Tofaris, Helen Gossage, Pam Tyers, M. G. Spillantini, RogerA Barker · 2007 · Cell Transplantation
  11. Alpha-synuclein’s degradation in vivo: Opening a new (cranial) window on the roles of degradation pathways in Parkinson disease
    Ebrahimi-Fakhari, Darius, McLean, Pamela J., Unni, Vivek K. · 2012 · Autophagy
  12. Mitochondrial Fusion/Fission, Transport and Autophagy in Parkinson's Disease: When Mitochondria Get Nasty
    Daniela M. Arduíno, A. Raquel Esteves, Sandra M. Cardoso · 2011 · Parkinson s Disease
  13. Carbonate Radical Ion Is the Only Observable Intermediate in the Reaction of Peroxynitrite with CO2
    Sara Goldstein, Gidon Czapski, Johan Lind, Gábor Merényi · 2001 · Chemical Research in Toxicology
  14. At Low Concentrations, 3,4-Dihydroxyphenylacetic Acid (DOPAC) Binds Non-Covalently to α-Synuclein and Prevents Its Fibrillation
    Wenbo Zhou, Amy Gallagher, Dong-Pyo Hong, Chunmei Long, Anthony L. Fink, Vladimir Nikolaevich Uversky · 2009 · Journal of Molecular Biology
  15. Mitochondrial dynamics and neuronal fate in Parkinson's disease
    Daniel Santos, Sandra M. Cardoso · 2012 · Mitochondrion
  16. Peroxynitrite as regulator of vascular prostanoid synthesis
    Stefan Schildknecht, Volker Ullrich · 2008 · Archives of Biochemistry and Biophysics
  17. α-Synuclein Elevation in Human Neurodegenerative Diseases: Experimental, Pathogenetic, and Therapeutic Implications
    Ayşe Ulusoy, Donato A. Di Monte · 2012 · Molecular Neurobiology
  18. α-Synuclein phosphorylation as a therapeutic target in Parkinson’s disease
    Steven P. Braithwaite, Jeffry B. Stock, M. Maral Mouradian · 2012 · Reviews in the Neurosciences
  19. Peroxynitrite provides the peroxide tone for PGHS‐2‐dependent prostacyclin synthesis in vascular smooth muscle cells
    Stefan Schildknecht, Markus Michael Bachschmid, Volker Ullrich · 2005 · The FASEB Journal
  20. A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease
    David K. Stone, Tomomi Kiyota, Rodney Lee Mosley, Howard Eliot Gendelman · 2012 · Neuroscience Letters
  21. May the Evaluation of Nitrosative Stress Through Selective Increase of 3-Nitrotyrosine Proteins Other Than Nitroalbumin and Dominant Tyrosine-125/136 Nitrosylation of Serum α-Synuclein Serve for Diagnosis of Sporadic Parkinson's Disease?
    Emilio Fernández‐Espejo, J. García-Moreno, Ángel Martín de Pablos, José Chacón · 2013 · Antioxidants and Redox Signaling
  22. Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice
    He-Jin Lee, Ji‐Eun Suk, Kyung-Won Lee, Seung-Hwa Park, Peter Charles Blumbergs, Wei‐Ping Gai, Seung‐Jae Lee · 2011 · Experimental Neurobiology
  23. Enhanced oligomerization of the alpha-synuclein mutant by the Cu,Zn-superoxide dismutase and hydrogen peroxide system.
    Jung Hoon Kang, Kyung Sik Kim · 2003 · PubMed
  24. The Reactions of the Hydroxyl Radical1
    Worth H. Rodebush, C. R. Keizer, Frances S. McKee, James V. Quagliano · 1947 · Journal of the American Chemical Society
  25. Enhanced Oligomerization of the α-Synuclein Mutant by the Cu,Zn-Superoxide Dismutase and Hydrogen Peroxide System
    Jung Hoon Kang, Kyung Sik Kim · 2003 · Molecules and Cells
  26. Kinetic measurements give new insights into lipidmembrane permeabilization by α-synuclein oligomers
    Martin Thomas Stöckl, Mireille M. A. E. Claessens, Vinod Subramaniam · 2011 · Molecular BioSystems
  27. Chemical model systems for cellular nitros(yl)ation reactions
    Andreas Daiber, Stefan Schildknecht, Johanna Müller, Jens Kamuf, Markus Michael Bachschmid, Volker Ullrich · 2009 · Free Radical Biology and Medicine
  28. The molecular mechanisms of dopamine toxicity.
    Ari Barzilai, Dorah Daily, Rina Zilkha‐Falb, Ilan Ziv, Daniel Offen, Eldad Melamed, Anat Shirvan · 2003 · PubMed
  29. Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
    Vladimir L. Buchman, Natalia N. Ninkina · 2008 · Neurotoxicity Research
  30. Locally Resolved Membrane Binding Affinity of the N-Terminus of α-Synuclein
    Marta Robotta, Christian Hintze, Stefan Schildknecht, Niels Zijlstra, Christian Jüngst, Christiaan Karreman, Martina Huber, Marcel Leist, Vinod Subramaniam, Malte Drescher · 2012 · Biochemistry
  31. Chemical Strategies for Controlling Protein Folding and Elucidating the Molecular Mechanisms of Amyloid Formation and Toxicity
    Sara M. Butterfield, Mirva Hejjaoui, Bruno Fauvet, Loay Awad, Hilal Ahmed Lashuel · 2012 · Journal of Molecular Biology
  32. Methionine Oxidation Stabilizes Non-Toxic Oligomers of alpha-synuclein through Strengthening the Auto-inhibitory Intra-molecular Long-range Interactions
    Wenbo Zhou, Chunmei Long, Stephen H. Reaney, Donato A. Di Monte, Anthony L. Fink, Vladimir Nikolaevich Uversky · 2013 · OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
  33. Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions
    Stefan Schildknecht · 2012 · ALTEX
  34. Sensing Hypoxia by Mitochondria: A Unifying Hypothesis Involving S-Nitrosation
    Volker Ullrich, Stefan Schildknecht · 2012 · Antioxidants and Redox Signaling
  35. Control of Aβ release from human neurons by differentiation status and RET signaling
    Diana Scholz, Yana Chernyshova, Marcel Leist · 2012 · Neurobiology of Aging
  36. Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages
    Stefan Schildknecht, Christiaan Karreman, Andreas Daiber, Cheng Zhao, Jürg Hamacher, David H. Perlman, Birgit Jung, Bernd van der Loo, Peter B. O’Connor, Marcel Leist et al. · 2012 · Antioxidants and Redox Signaling
  37. Induction of Nitric Oxide Synthase-2 Expression and Measurement of Nitric Oxide Production in Enriched Primary Cortical Astrocyte Cultures
    James A. Hewett, Sandra J. Hewett · 2011 · Methods in molecular biology
  38. ENVIRONMENTAL TOXINS IN PARKINSON'S DISEASE
    P. Vieregge, Detlef Kömpf, Horst Fassl · 1988 · The Lancet