Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease

Cited by (170)

Items 101–170 of 170

1. Why are neurotransmitters neurotoxic? An evolutionary perspective
   Keith D. Harris, Meital Weiss, Amotz Avishag Zahavi · 2014 · F1000Research
2. Synaptic alterations and immune response are sexually dimorphic in a non-pertussis toxin model of experimental autoimmune encephalomyelitis
   Kayla Murphy, R. Fischer, Kathryn A Swanson, Ishaan J. Bhatt, L. Oakley, Richard J Smeyne, V. Bracchi-Ricard, J. Bethea · 2019 · Experimental Neurology
3. Herpes Simplex Virus Type 1 Neuronal Infection Triggers the Disassembly of Key Structural Components of Dendritic Spines
   Francisca Acuña, Adriana Covarrubias‐Pinto, Yuta Ishizuka, María Francisca Stolzenbach, Carolina Martín, Paula Salazar, Maite A. Castro, Clive R. Bramham, Carola Otth L · 2021 · Frontiers in Cellular Neuroscience
4. Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease
   Margaret G. O’Connor, Yangping Shentu, Guan Wang, Wenting Hu, Zhendong Xu, Xiaochuan Wang, Rong Liu, Heng‐Ye Man · 2020 · iScience
5. Synaptic and Sub-Synaptic Localization of Amyloid-β Protein Precursor in the Rat Hippocampus
   Diana I. Rodrigues, Jessié Martins Gutierres, Anna Pliássova, Catarina Resende Oliveira, Rodrigo Antunes Cunha, Paula M. Agostinho · 2014 · Journal of Alzheimer s Disease
6. Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-β Peptides Modeling Alzheimer’s Disease
   João A. Amorim, Paula M. Canas, Ângelo R. Tomé, Anabela Pinto Rolo, Paula M. Agostinho, Carlos M. Palmeira, Rodrigo Antunes Cunha · 2017 · Journal of Alzheimer s Disease
7. A Functional SNP Catalog of Overlapping miRNA-Binding Sites in Genes Implicated in Prion Disease and Other Neurodegenerative Disorders
   Reuben Saba, Sarah J. Medina, Stephanie A. Booth · 2014 · Human Mutation
8. Quantitative Assessment of Cortical Excitability in Alzheimer’s Dementia and Its Association with Clinical Symptoms: A Systematic Review and Meta-Analyses
   Shaylyn Joseph, Rachel Patterson, Wei Wang, Daniel M. Blumberger, Tarek K. Rajji, Sanjeev Kumar · 2021 · Journal of Alzheimer s Disease
9. Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice
   Jie Gao, Lijun Wang, Chenyi Zhao, Yongkang Wu, Zhiyuan Lu, Yining Gu, Zongtao Ba, Xingyu Wang, Jian Wang, Ying Xu · 2021 · Journal of Leukocyte Biology
10. Electrophysiological differences in cortical excitability in different forms of dementia: A transcranial magnetic stimulation and laboratory biomarkers study
    Eman Mohamed Khedr, Omyma G Ahmed, Hanaa MM Sayed, Noha Abo Elfetoh, Anwar Mohamed Ali, Asmaa M. S. Gomaa · 2020 · Neurophysiologie Clinique
11. The Density of Group I mGlu5 Receptors Is Reduced along the Neuronal Surface of Hippocampal Cells in a Mouse Model of Alzheimer’s Disease
    Alejandro Martín‐Belmonte, Carolina Aguado, Rocío Alfaro‐Ruiz, José Luís Albasanz, Mairena Martı́n, Ana Esther Moreno‐Martínez, Yugo Fukazawa, Rafael Luján · 2021 · International Journal of Molecular Sciences
12. Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Is Not a Major Determining Factor in the Development of Sporadic Alzheimer Disease: Evidence from an Updated Meta-Analysis
    Wang, Xue-bin, Cui, Ning-hua, Yang, Jie, Qiu, Xue-ping, Gao, Jia-jia, Yang, Na, Zheng, Fang · 2014 · PLoS ONE
13. Floralozone improves cognitive impairment in vascular dementia rats via regulation of TRPM2 and NMDAR signaling pathway
    Yaling Yin, Yanhua Liu, Mo‐Li Zhu, Huanhuan Wang, Yue Qiu, Guang‐Rui Wan, Peng Li · 2022 · Physiology & Behavior
14. Exercise Alleviates Behavioral Disorders but Shapes Brain Metabolism of APP/PS1 Mice in a Region- and Exercise-Specific Manner.
    Na Ying, Hanqi Luo, Bai-Xia Li, Kai-Yan Gong, Qi Shu, Fei Liang, Hongchang Gao, Tao Huang, Hong Zheng · 2023 · Journal of Proteome Research
15. Urine biomarkers for Alzheimer's disease: A new opportunity for wastewater-based epidemiology?
    Arnoldo Armenta-Castro, Mónica T. Núñez-Soto, Kassandra O. Rodríguez-Aguillón, Alberto Aguayo-Acosta, Mariel Araceli Oyervides-Muñoz, Shane A. Snyder, ‪Damià Barceló, Jayaprakash Saththasivam, Jenny Lawler, Juan Eduardo Sosa‐Hernández et al. · 2024 · Environment International
16. Involvement of ‘stress–response’ kinase pathways in Alzheimer's disease progression
    Georges Mairet‐Coello, Franck Polleux · 2014 · Current Opinion in Neurobiology
17. Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity
    Danielle M. Osborne, Dennis P. Fitzgerald, Kelsey E. O’Leary, Brian M. Anderson, Christine C. Lee, Peter M. Tessier, Ewan C. McNay · 2016 · Biochimica et Biophysica Acta (BBA) - General Subjects
18. Catechins as a Potential Dietary Supplementation in Prevention of Comorbidities Linked with Down Syndrome
    Christophe Noll, Janany Kandiah, Gautier Moroy, Yuchen Gu, Julien Dairou, Nathalie Janel · 2022 · Nutrients
19. Ion Pairing of the Neurotransmitters Acetylcholine and Glutamate in Aqueous Solutions
    Sergey E. Kruchinin, Marina V. Fedotova · 2021 · The Journal of Physical Chemistry B
20. Reduced serine racemase expression in aging rat cerebellum is associated with oxidative DNA stress and hypermethylation in the promoter
    He Zhang, Xiuli Kuang, Yuhua Chang, Jinfang Lu, Haiyan Jiang, Shengzhou Wu · 2015 · Brain Research
21. Borneol and lactoferrin dual-modified crocetin-loaded nanoliposomes enhance neuroprotection in HT22 cells and brain targeting in mice
    Zheren Tong, Xiao‐Lu Jie, Ziwei Chen, Mingtao Deng, Xin Li, Zhiwen Zhang, Faxiang Pu, Zhangfu Xie, Zijin Xu, Ping Wang · 2024 · European Journal of Medicinal Chemistry
22. Autophagy-ERK1/2-Involved Disinhibition of Hippocampal Neurons Contributes to the Pre-Synaptic Toxicity Induced by Aβ 42 Exposure
    Yanling Yin, Yuanyuan Zhao, Song Han, Nan Zhang, Hanyu Chen, Xiaomin Wang · 2017 · Journal of Alzheimer s Disease
23. Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca2+ release, and Wnt-5a/Ca2+ signaling: opposing roles in neuronal mitochondrial dynamics?
    Andrea Cristina Paula-Lima, Cecilia Hidalgo · 2013 · Frontiers in Cellular Neuroscience
24. LY379268 Does Not Have Long-Term Procognitive Effects nor Attenuate Glutamatergic Signaling in AβPP/PS1 Mice
    Kevin N. Hascup, Jesse Britz, Caleigh A. Findley, Shelley A. Tischkau, Erin R. Hascup · 2019 · Journal of Alzheimer s Disease
25. Amyloid β-Oligomers Inhibit the Nuclear Ca2+ Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons
    Pedro Lobos, Ignacio Vega-Vásquez, Bárbara Bruna, Silvia Gleitze, Jorge A. Toledo, Steffen Härtel, Cecilia Hidalgo, Andrea Cristina Paula-Lima · 2023 · Antioxidants
26. Excitatory-inhibitory synaptic imbalance induced by acute intra-hippocampus injections of amyloid-β oligomers
    Jorge Arriagada, Daymara Mercerón‐Martínez, Álvaro O. Ardiles, Pablo Muñoz, Andrea Cristina Paula-Lima · 2024 · Biochemical and Biophysical Research Communications
27. Chemoselective and enantioselective fluorescent recognition of basic amino acids: A review
    Fang-Qi Zhang, Zhiyong Xu, Li Yang, Yuan‐Yuan Zhu, Shuang‐Xi Gu · 2025 · Dyes and Pigments
28. Alzheimer’s genetic risk factor Bin1 controls synapse vesicle exo-endocytosis in inhibitory synapses
    Mariana Afonso Barata, Catarina Perdigão, Jose Silva Ramalho, Edgar R. Gomes, Cláudia Guimas Almeida · 2025 · Cell Reports
29. Metabolic dysregulation in Alzheimer's disease: A brain metabolomics approach
    Anke Hüls, Youran Tan, Emma Casey, Zhenjiang Li, Marla Gearing, Allan I. Levey, James J. Lah, Aliza P. Wingo, Dean P. Jones, Douglas I Walker et al. · 2025 · Alzheimer s & Dementia
30. Genetically and pharmacologically limiting RyR2 open time prevents neuronal hyperactivity of hippocampal CA1 neurons in brain slices of 5xFAD mice
    Bo Sun, Jinjing Yao, Alexander W. Chen, John Paul Estillore, Ruiwu Wang, Thomas George Back, S.R. Wayne Chen · 2021 · Neuroscience Letters
31. Adansonia digitata ameliorates lead-induced memory impairments in rats by reducing glutamate concentration and oxidative stress
    Eduitem Sunday Otong, Sunday Abraham Musa, Barnabas Danborno, Sohnap James Sambo, Nathan Isaac Dibal · 2021 · Egyptian Journal of Basic and Applied Sciences
32. Why are neurotransmitters neurotoxic? An evolutionary perspective
    Keith Daniel Harris, Meital Weiss, Amotz Avishag Zahavi · 2014 · F1000Research
33. CHF5074 and LY450139 sub-acute treatments differently affect cortical extracellular glutamate levels in pre-plaque Tg2576 mice
    Sarah Beggiato, Alessandro Giuliani, Sandra Sivilia, Luca Lorenzini, Tiziana Antonelli, Bruno Pietro Imbimbo, Luciana Giardino, Laura Calzà, Luca Ferraro · 2014 · Neuroscience
34. MR spectroscopy in Alzheimer’s disease
    Nasim Sheikh‐Bahaei · 2020 · Biomedical Spectroscopy and Imaging
35. Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
    You-Chang Oh, Yun Hee Jeong, Hye Jin Yang, Wei Li, Jin Yeul · 2023 · Current Issues in Molecular Biology
36. The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
    Yun Hee Jeong, You-Chang Oh, Tae In Kim, Jong‐Sup Bae, Jin Yeul · 2022 · Current Issues in Molecular Biology
37. Identification of the Microbiota in the Aging Process
    Amar Sarkar, Capecomorin S. Pitchumoni · 2017 · Elsevier eBooks
38. Isotope‐Labeled Chemoselective Probes for Labeling, Separation, and Comprehensive Quantitative Analysis of Sub‐Metabolome
    Hongtao Tian, Zhizhen Lai, Wenjia Zhang, Mo Zhang, Xiaolin Yang, Jiang Zhou, Zhili Li · 2024 · Small Methods
39. Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons
    Kishoree Krishna Kumaree, James Michael Brimson, Kanika Verma, Siriporn Chuchawankul, Tewin Tencomnao, Anchalee Prasansuklab · 2025 · Scientific Reports
40. A fluorescent probe for enantioselective recognition of amino acids in solutions, cells and zebrafishes
    Shiwei Fu, Zong-Xing Huang, Chuan-Zhi Ni, Fang-Qi Zhang, Li Yang, Yuan‐Yuan Zhu, Qi Sun, Shuang‐Xi Gu · 2025 · Dyes and Pigments
41. Early involvement of D-serine in β-amyloid-dependent pathophysiology
    Jean‐Marie Billard, Eva Ploux, Stacy Largillière, Sophie Corvaisier, Lucie Gorisse-Hussonnois, Inna S. Radzishevsky, Herman Wolosker, Thomas Fréret · 2025 · Cellular and Molecular Life Sciences
42. Cholesterol and Fat Metabolism in Alzheimer’s Disease
    Changiz Taghibiglou, Siavash Khalaj · 2016 · Elsevier eBooks
43. Protective Effect of 2′,3′-Dihydroxy-4′,6′-dimethoxychalcone on Glutamate-Induced Neurotoxicity in Primary Cortical Cultures
    Kazuya Taguchi, Yasuhiko Izumi, Yuki Takada‐Takatori, Akinori Akaike, Toshiaki Kume · 2019 · Biological and Pharmaceutical Bulletin
44. The Switching Rates of Dynamic Functional Networks Differently Contribute to Cross-Sectional and Longitudinal Cognition in Mild Cognitive Impairment
    Zhen Hu, Yulei Deng, Binyin Li · 2022 · Journal of Integrative Neuroscience
45. A Comprehensive Review of Membrane Transporters and MicroRNA Regulation in Alzheimer’s Disease
    Shatakshi Mishra, Bala Kumar Stany, Anushka Das, Kanagavel Deepankumar, Murali Vijayan · 2024 · Molecular Neurobiology
46. A combination of Δ9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer's disease
    Núria Sánchez-Fernández, Laura Gómez-Acero, Anna Castañé, Albert Adell, Leticia Campa, Jordi Bonaventura, Verónica Brito, Sílvia Ginés, Francisco Queiróz, Henrique Bruno Lopes Silva et al. · 2024 · Neurotherapeutics
47. Clinical insights into catechin-based nanomedicine: a review of therapeutic potential in neurodegenerative diseases
    Md. Al Amin, Mehrukh Zehravi, Sherouk Hussein Sweilam, Thukani Sathanantham Shanmugarajan, Uppuluri Varuna Naga Venkata Arjun, Mogan Babu Nagaiyan, S. Mounika Reddy, Vijayakumar Subash, Kalam Mary swarnalatha, Arjun Pazhanikumar et al. · 2025 · 3 Biotech
48. DNA Methylation in Psychiatric Diseases
    Michel Neidhart · 2015 · Elsevier eBooks
49. Effects of Bioactive Components of Green Tea on Alzheimer's Disease
    Kazuki Ide, Yohei Kawasaki, Koji Kawakami, Hiroshi Yamada · 2018 · Studies in natural products chemistry
50. Therapeutic Potential and Recent Development of Psychobiotics for the Management of Brain Disorders
    Ajit Kumar Thakur, Ubaid Tariq · 2019 · Trends in Applied Sciences Research
51. The protect role of Hydrogen sulfide in gastric injury
    Nirmal Verma · 2014 · Inflammation and Cell Signaling
52. SMPL Synaptic Membranes: Nanodisc-Mediated Synaptic Membrane Mimetics Expand the Toolkit for Drug Discovery and the Molecular Cell Biology of Synapses
    Riana Lo Bu, Jeffrey R. Clark, Thomas DiChiara, Stephen G. Sligar, William L. Klein · 2018 · Neuromethods
53. Identification of benzimidazole-6-carboxamide based inhibitors of secretory glutaminyl cyclase for the treatment of Alzheimer's disease
    Kalarickal Vijayan Dileep, Naoki Sakai, Kentaro Ihara, Akiko Nakata, Akihiro Ito, Divya Mundackal Sivaraman, Chi Wai Yip, Jay W. Shin, Minoru Yoshida, Mikako Shirouzu et al. · 2024 · International Journal of Biological Macromolecules
54. Metformin enhances hippocampal excitatory synaptic transmission and preserves synaptic plasticity under amyloid-β oligomer-induced dysfunction
    Jorge Arriagada, Álvaro O. Ardiles, Elena Mery, Camila Garay, Felipe Conejera, Emilio A. Herrera, Andrea Cristina Paula-Lima, Pablo Muñoz · 2026 · Neuropharmacology
55. Dopamine and Glutamate Dysfunction in a Rodent Model of Attention-Deficit/Hyperactivity Disorder: Implications for Future Neuropharmacology
    Erin M. Miller · 2014 · UKnowledge (University of Kentucky)
56. Aβ-mediated changes in CREB and ERK activity in cultured cortical neurons : involvement of NMDA receptors
    Valéria de Rosa · 2013
57. Remodelado del Ca2+ Intracelular en el cáncer colorrectal: descripción, bases moleculares y consecuencias funcionales
    Diego Sobradillo Luengo · 2015
58. Knockout of the glutamate transporter GLT-1 specifically from neurons drastically alters transcriptome profiles in CA3, CA1, and Striatum
    Alexander Cory Wright Houston · 2015 · DSpace@MIT (Massachusetts Institute of Technology)
59. Neurotrophin receptor p75 affords clearance of amyloid beta in Alzheimer’s disease and provides targeting route to basal forebrain cholinergic neurons
    Inga Antyborzec · 2016 · Dublin City University Open Access Institutional Repository (Dublin City University)
60. Peer Reviewed Title: D-serine levels in Alzheimer's disease: Implications for novel biomarker development
    UC San Francisco · 2015
61. Neurochemical Aspects of β-Amyloid Cascade Hypothesis for Alzheimer’s Disease
    A. A. Farooqui · 2017 · Elsevier eBooks
62. Alzheimer’s Disease Implications and its Strategies
    Khadar Khan · 2021 · Journal of Bioequivalence & Bioavailability
63. Influence of Amino Acids on Autism and Attention-Deficit Hyperactive Disorder
    Pathan Shajahan Begum, Meerza Abdul Razak, Senthilkumar Rajagopal · 2022 · Nutritional neurosciences
64. Editorial: Molecular mechanisms of Alzheimer’s disease: From top to bottom
    Pâmela Billig Mello‐Carpes, Nibaldo C. Inestrosa, Andrea Cristina Paula-Lima · 2022 · Frontiers in Aging
65. Applications of Nanotechnology in Medical Science
    2022 · International Journal of Bio-Medical Informatics and e-Health
66. Cholesterol, lipid metabolism, and lipid rafts in Alzheimer's disease
    Changiz Taghibiglou, Mahboubeh Pordeli, Elina Setork, Francisco S. Cayabyab · 2025 · Elsevier eBooks
67. Synaptic Dysfunction in Alzheimer’s Disease: A Narrative Review of Neuronal Changes
    Gamze Doğan, Guvem Gumus Akay · 2025 · Ankara Üniversitesi Tıp Fakültesi Mecmuası
68. SGK1 inhibition restores excitability of cortical neurons derived from Alzheimer's disease patients
    Zhongjiao Jiang, Komal Saleem, Emily Fisher, Li Li, Zhen Yan, Jian Feng · 2026 · Neurobiology of Disease
69. Selective weakening of population-coupled synaptic activity in vivo in a mouse model of amyloid-beta pathology
    Leire Melgosa-Ecenarro, Carola I. Radulescu, Nazanin Doostdar, Joe Airey, Francesca A. Chaloner, Nawal Zabouri, Giada Pedretti, Francesca Osso, Leire Garrido Perez, Kjara S Pilch et al. · 2026 · Nature Communications
70. Protocol for semi-automatic quantitative bioimaging analysis of synapse loss
    Mariana Afonso Barata, Cláudia Guimas Almeida · 2026 · STAR Protocols