The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Overexpression of MzASMT improves melatonin production and enhances drought tolerance in transgenic Arabidopsis thaliana plants
Abstract
Melatonin is a potent naturally occurring reactive oxygen species (ROS) and reactive nitrogen species (RNS) scavenger in plants. Melatonin protects plants from oxidative stress and, therefore, it improves their tolerance against a variety of environmental abiotic stressors. N‐acetylserotonin‐O‐methyltransferase (ASMT) is a specific enzyme required for melatonin synthesis. In this report, an ASMT gene was cloned from apple rootstock (Malus zumi Mats) and designated as Mz ASMT 1 (KJ 123721). The Mz ASMT 1 expression was induced by drought stress in apple leaves. The upregulation of Mz ASMT 1 in the apple leaf positively relates to melatonin production over a 24‐hr dark/light cycle. Purified Mz ASMT 1 protein expressed in E. coli converted its substrates to melatonin with an activity of approximately 5.5 pmol/min/mg protein. The transient transformation in tobacco identified that Mz ASMT 1 is located in cytoplasm of the cell. When Mz ASMT 1 gene driven by 35S promoter was transferred to Arabidopsis, melatonin levels in transgenic Arabidopsis plants were 2–4 times higher than those in the wild type. The transgenic Arabidopsis plants had significantly lower intrinsic ROS than the wild type and therefore these plants exhibited greater tolerance to drought stress than that of wild type. This is, at least partially, attributed to the elevated melatonin levels resulting from the overexpression of Mz ASMT 1. The results elucidated the important role that membrane‐located melatonin synthase plays in drought tolerance. These findings have significant implications in agriculture.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Reactive oxygen species: Metabolism, oxidative stress, and signal transduction
Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601
Hydrogen peroxide and nitric oxide as signalling molecules in plants
Neill, S. J. (2002) · Journal of Experimental Botany · doi:10.1093/jexbot/53.372.1237 · Cited by 1,225
Dubbels, R., Reiter, R. J., Klenke, E., Goebel, A., Schnakenberg, E., Ehlers, C., Schiwara, H. W., & Schloot, W. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00136.x · Cited by 1,103
Tan, D.-X., Reiter, R., Manchester, L., Yan, M.-T., El-Sawi, M., Sainz, R., Mayo, J., Kohen, R., Allegra, M., & Hardelan, R. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394443 · Cited by 1,065
Bailly, C., El-Maarouf-Bouteau, H., & Corbineau, F. (2008) · Comptes Rendus. Biologies · doi:10.1016/j.crvi.2008.07.022 · Cited by 861
Hattori, A., Migitaka, H., Iigo, M., Itoh, M., Yamamoto, K., Ohtani‐Kaneko, R., Hara, M., Suzuki, T., & Reiter, R. J. (1995) · PubMed · Cited by 827
On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK
Galano, A., Tan, D. X., & Reiter, R. J. (2013) · Journal of Pineal Research · doi:10.1111/jpi.12010 · Cited by 795
Plant Response and Tolerance to Abiotic Oxidative Stress: Antioxidant Defense Is a Key Factor
Hasanuzzaman, M., Hossain, M. A., da Silva, J. A. T., & Fujita, M. (2012) · Crop Stress and its Management: Perspectives and Strategies · doi:10.1007/978-94-007-2220-0_8 · Cited by 671
Zhang, N., Zhao, B., Zhang, H., Weeda, S., Yang, C., Yang, Z., Ren, S., & Guo, Y. (2013) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2012.01015.x · Cited by 636
Cited by
Functions of melatonin in plants: a review
Arnao, M. B., & Hernández‐Ruiz, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12253 · Cited by 889
Melatonin Synthesis and Function: Evolutionary History in Animals and Plants
Zhao, D., Yu, Y., Shen, Y., Liu, Q., Zhao, Z., Sharma, R., & Reiter, R. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00249 · Cited by 689
Melatonin: A master regulator of plant development and stress responses
Sun, C., Liu, L., Wang, L., Li, B., Jin, C., & Lin, X. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12993 · Cited by 494
Self-citationMelatonin metabolism, signaling and possible roles in plants
Back, K. (2021) · The Plant Journal · doi:10.1111/tpj.14915 · Cited by 281
Metadata
- Authors
- Zuo, B., Zheng, X., He, P., Wang, L., Lei, Q., Feng, C., Zhou, J., Li, Q., Han, Z., & Kong, J.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2014-10-16
- Volume
- 57
- Issue
- 4
- Pages
- 408-417
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2033027655
- Cited by
- 254
- References
- 49
- FWCI
- 16.58
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Overexpression of MzASMT improves melatonin production and enhances drought tolerance in transgenic Arabidopsis thaliana plants. https://app.cochat.ai/papers/10.1111/jpi.12180
- The paper
- Zuo, B., Zheng, X., He, P., Wang, L., Lei, Q., Feng, C., Zhou, J., Li, Q., Han, Z., & Kong, J. (2014). Overexpression of MzASMT improves melatonin production and enhances drought tolerance in transgenic Arabidopsis thaliana plants. Journal of Pineal Research. https://doi.org/10.1111/jpi.12180
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
