The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts
Abstract
Melatonin is an animal hormone as well as a signaling molecule in plants. It was first identified in plants in 1995, and almost all enzymes responsible for melatonin biosynthesis had already been characterized in these species. Melatonin biosynthesis from tryptophan requires four‐step reactions. However, six genes, that is, TDC, TPH, T5H, SNAT, ASMT, and COMT, have been implicated in the synthesis of melatonin in plants, suggesting the presence of multiple pathways. Two major pathways have been proposed based on the enzyme kinetics: One is the tryptophan/tryptamine/serotonin/N‐acetylserotonin/melatonin pathway, which may occur under normal growth conditions; the other is the tryptophan/tryptamine/serotonin/5‐methoxytryptamine/melatonin pathway, which may occur when plants produce large amounts of serotonin, for example, upon senescence. The melatonin biosynthetic capacity associated with conversion of tryptophan to serotonin is much higher than that associated with conversion of serotonin to melatonin, which yields a low level of melatonin synthesis in plants. Many melatonin intermediates are produced in various subcellular compartments, such as the cytoplasm, endoplasmic reticulum, and chloroplasts, which either facilitates or impedes the subsequent enzymatic steps. Depending on the pathways, the final subcellular sites of melatonin synthesis vary at either the cytoplasm or chloroplasts, which may differentially affect the mode of action of melatonin in plants.
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Cites
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
Manchester, L. C., Coto‐Montes, A., Boga, J. A., Andersen, L. P. H., Zhou, Z., Galano, A., Vriend, J., Tan, D., & Reiter, R. J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12267 · Cited by 945
Self-citationFunctions of melatonin in plants: a review
Arnao, M. B., & Hernández‐Ruiz, J. (2015) · Journal of Pineal Research · doi:10.1111/jpi.12253 · Cited by 889
Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism
Tan, D.-X., Manchester, L., Esteban-Zubero, E., Zhou, Z., & Reiter, R. (2015) · Molecules · doi:10.3390/molecules201018886 · Cited by 719
Self-citationMelatonin: plant growth regulator and/or biostimulator during stress?
Arnao, M. B., & Hernández-Ruiz, J. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2014.07.006 · Cited by 674
Roles of melatonin in abiotic stress resistance in plants
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Self-citationShi, H., Jiang, C., Ye, T., Tan, D.-X., Reiter, R. J., Zhang, H., Liu, R., & Chan, Z. (2015) · Journal of Experimental Botany · doi:10.1093/jxb/eru373 · Cited by 554
Self-citationTetrahydropterin-Dependent Amino Acid Hydroxylases
Fitzpatrick, P. F. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.355 · Cited by 513
GCN5-Related N-Acetyltransferases: A Structural Overview
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Melatonin promotes ripening and improves quality of tomato fruit during postharvest life
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Melatonin Synthesis and Function: Evolutionary History in Animals and Plants
Zhao, D., Yu, Y., Shen, Y., Liu, Q., Zhao, Z., Sharma, R., & Reiter, R. J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00249 · Cited by 689
Self-citationMelatonin as a mitochondria-targeted antioxidant: one of evolution's best ideas
Reiter, R. J., Rosales-Corral, S., Tan, D. X., Jou, M. J., Galano, A., & Xu, B. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2609-7 · Cited by 558
Self-citationMelatonin: A master regulator of plant development and stress responses
Sun, C., Liu, L., Wang, L., Li, B., Jin, C., & Lin, X. (2021) · Journal of Integrative Plant Biology · doi:10.1111/jipb.12993 · Cited by 494
Mitochondria: Central Organelles for Melatonin′s Antioxidant and Anti-Aging Actions
Reiter, R., Tan, D., Rosales-Corral, S., Galano, A., Zhou, X., & Xu, B. (2018) · Molecules · doi:10.3390/molecules23020509 · Cited by 393
Self-citationRONS and Oxidative Stress: An Overview of Basic Concepts
Aranda-Rivera, A. K., Cruz-Gregorio, A., Arancibia-Hernández, Y. L., Hernández-Cruz, E. Y., & Pedraza-Chaverri, J. (2022) · Oxygen · doi:10.3390/oxygen2040030 · Cited by 384
Metadata
- Authors
- Back, K., Tan, D., & Reiter, R. J.
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2016-09-24
- Volume
- 61
- Issue
- 4
- Pages
- 426-437
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2518394958
- Cited by
- 536
- References
- 75
- FWCI
- 12.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- Back, K., Tan, D., & Reiter, R. J. (2016). Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts. Journal of Pineal Research. https://doi.org/10.1111/jpi.12364
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