Periodontitis GWAS Reveal Immune‐Biased Heritability Without Gingival Cell‐Type Resolution
Open accessAbstract
Three methodologically distinct analyses partition periodontitis common-variant heritability across 27 gingival cell types. They agree on an immune-over-stromal direction but nominate three different top cell types, and a low-power analysis inverts the fibroblast signal; the current periodontitis GWAS therefore cannot resolve heritability to a single gingival cell type.
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Cites
Plasma proteomic associations with genetics and health in the UK Biobank
Sun, B. B., Chiou, J., Traylor, M., Benner, C., Hsu, Y.-H., Richardson, T. G., Surendran, P., Mahajan, A., Robins, C., Vasquez-Grinnell, S. G., et al. (2023) · Nature · doi:10.1038/s41586-023-06592-6 · Cited by 1,740 · see citing works
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- Authors
- Wang, C., An, W., Lin, M., Wang, Y., & Yang, G.
- Affiliations
- Zhejiang University Medical College Affiliated Stomatological Hospital (CN)
- Corresponding author
- Yang, Guoli
- Venue
- Journal of Periodontal Research
- Publisher
- Wiley
- Published
- 2026-10-07
- ISSN
- 0022-3484 (ISSN-L)
- 1600-0765
- OpenAlex
- W7220833253
- Cited by
- 0
- References
- 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Periodontal Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (82101061)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Health Professions › Pharmacy › Oral and gingival health research
- Keywords
- periodontitis, fibroblasts, genetic architecture, periodontal disease genetics
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