Serial measurement of pancreatic lipase immunoreactivity concentration in dogs with immune‐mediated disease treated with prednisolone
Open accessAbstract
Objectives: In this pilot study, serum canine pancreatic lipase immunoreactivity was measured repeatedly in dogs with various immune‐mediated diseases that were treated with immunosuppressive doses of prednisolone. Methods: Ten client‐owned dogs with newly diagnosed immune‐mediated disease that had normal canine pancreatic lipase immunoreactivity concentrations (≤200 µg/l) were treated with 2 to 2.2 mg/kg prednisolone orally once daily as the initial treatment. Serum samples were obtained from each of the dogs prior to treatment and at 1‐ to 4‐week intervals during immunosuppressive treatment. The highest canine pancreatic lipase immunoreactivity concentration detected during immunosuppressive treatment was defined as the peak canine pancreatic lipase immunoreactivity. Results: Peak canine pancreatic lipase immunoreactivity concentrations were classified as normal in two dogs, questionable (201 to 399 µg/l) in three dogs, and abnormal (≥400 µg/l) in five dogs. Peak canine pancreatic lipase immunoreactivity concentrations were significantly higher than baseline canine pancreatic lipase immunoreactivity concentrations but there was no evidence of clinical pancreatitis. Clinical Significance: It remains unclear whether the five of 10 dogs with elevated canine pancreatic lipase immunoreactivity during prednisone treatment had subclinical pancreatitis or whether the abnormal results were a consequence of prednisolone administration.
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Hepatic TDO is strongly regulated by glucocorticoids, while IDO is immune responsive.
“Importantly, hepatic TDO is strongly regulated by glucocorticoids (Danesch et al., 1983;Ohta et al., 2017), while IDO is immune responsive.”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Ohta et al., 2017
The Introduction and Discussion describe prednisolone treatment and pancreatic lipase measurements in dogs, not regulation of hepatic TDO or immune responsiveness of IDO. Searches of our copy for TDO and IDO returned no passages addressing either enzyme. Page numbers were not available in the indexed passages. (LLM, conf=0.76)
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The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347 · see citing works
- Authors
- Ohta, H., Morita, T., Yokoyama, N., Osuga, T., Sasaki, N., Morishita, K., Nakamura, K., & Takiguchi, M.
- Affiliations
- Hokkaido University (JP)
- Corresponding author
- Ohta, H.
- Venue
- Journal of Small Animal Practice
- Publisher
- Wiley
- Published
- 2017-03
- Volume
- 58
- Issue
- 6
- Pages
- 342-347
- ISSN
- 0022-4510 (ISSN-L)
- 1748-5827
- OpenAlex
- W2594606776
- Cited by
- 25
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 2 · 2022: 4 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 1
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Journal of Small Animal Practice (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Hokkaido University Collection of Scholarly and Academic Papers (Hokkaido University) (submittedVersion)
- Topics
- Health Sciences › Veterinary › Small Animals › Veterinary Medicine and Surgery
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- prednisolone, immune-mediated diseases, dogs, immunosuppressive therapy, serum biomarkers
- MeSH terms
- Animals, Dog Diseases, Dogs, Female, Lipase, Male, Pancreas, Pilot Projects, Prednisolone
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