Commentary on: Circulating plasmablasts contribute to antiphospholipid antibody production, associated with type I interferon upregulation
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In single LAC-positive samples negative for antiβ2GPI and anti-PS/PT antibodies, the antibody is not directed toward the known antigens but might be directed against other plasma proteins.
“In single LAC-positive samples,negativeforantiβ 2GPIandanti-PS/PTantibodies,the antibody is not directed toward the known antigens but might be directed against other plasma proteins. 24,25”
From Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome (2021) · cites this paper as [25]
The commentary discusses heterogeneous antiphospholipid antibodies and lists APS laboratory tests, but it does not address isolated LAC-positive samples negative for anti-β2GPI and anti-PS/PT. Searches for that combination and for alternative plasma-protein targets found no passage establishing the proposed target. (LLM, conf=0.72)
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Cites
Chayoua, W., Kelchtermans, H., Moore, G. W., Musiał, J., Wahl, D., de Laat, B., & Devreese, K. M. J. (2018) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.14261 · Cited by 71 · see citing works
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Research works printed but not linked: 6
- Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, et al. International consensus statement on an update of the clas- sification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006;4(2):295-306.
- Du VX, Kelchtermans H, de Groot PG, de Laat B. From antibody to clinical phenotype, the black box of the antiphospholipid syndrome: pathogenic mechanisms of the antiphospholipid syndrome. Thromb Res. 2013;132(3):319-26.
- Hisada R, Kato M, Sugawara E, Kanda M, Fujieda Y, Oku K, et al. Circulating plasmablasts contribute to antiphospholipid antibody production, associ- ated with type I interferon upregulation. J Thromb Haemost. 2019. https ://doi.org/10.1111/jth.14427 [Epub ahead of print]. · DOI
- Shanahan JC, Moreland LW, Carter RH. Upcoming biologic agents for the treatment of rheumatic diseases. Curr Opin Rheumatol. 2003;15(3):226-36.
- Iverson GM, Victoria EJ, Marquis DM. Anti-beta2 glycoprotein I (beta2GPI) autoantibodies recognize an epitope on the first domain of beta2GPI. Proc Natl Acad Sci USA. 1998;95(26):15542-6.
- Ioannou Y, Pericleous C, Giles I, Latchman DS, Isenberg DA, Rahman A. Binding of antiphospholipid antibodies to discontin- uous epitopes on domain I of human beta(2)-glycoprotein I: mu- tation studies including residues R39 to R43. Arthritis Rheum. 2007;56(1):280-90.
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Yin, D., de Groot, P. G., Ninivaggi, M., Devreese, K. M. J., & de Laat, B. (2021) · Thrombosis and Haemostasis · doi:10.1055/a-1344-4271 · Cited by 36 · see citing works
Self-citation
- Authors
- Yin, D., & de Laat, B.
- Affiliations
- Synapse (Netherlands) (NL)
- ORCID
- Yin, Dongmei
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 17
- Issue
- 7
- Pages
- 1030-1032
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W2955333608
- Cited by
- 4
- References
- 1
- Citations by year
- 2026: 2 · 2023: 1 · 2020: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Keywords
- antiphospholipid syndrome, antiphospholipid antibodies, plasmablasts, type I interferon, beta2-glycoprotein I, anticardiolipin antibodies, thrombosis, pregnancy morbidity, autoantibody production
- MeSH terms
- Antibody Formation, Interferon Type I, Plasma Cells, Up-Regulation, Antibodies, Antiphospholipid
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