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Guidance on the critical shortage of sodium citrate coagulation tubes for hemostasis testing
Open accessAbstract
Recent manufacturing problems and increased utilization has created a shortage of 3.2% sodium citrate blood collection tubes used for coagulation testing, causing stakeholders such as hospitals, clinics and laboratories, to find suitable alternatives. Considerations for in-house citrate blood collection tube preparations or purchasing commercial products from unknown manufacturing sources is of particular concern to laboratories that perform coagulation testing. It is well recognized that variability exists between citrate blood collection tube manufacturers, thereby making any transition to new blood collection methods more challenging than simply switching to a new source. This document provides provisional guidance for validating alternative sources of sodium citrate blood collection tubes (commercial or in-house preparations) prior to clinical implementation.
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References 15 · Cited by 25
Research works printed but not linked: 1
- CLSI. Collection, transport, and processing of blood specimens for testing plasma‐based coagulation assays and molecular hemostasis assays; Approved Guideline ‐ Fifth Edition. CLSI document H21‐A5. 2008. Clinical and Laboratory Standards Institute. Wayne, PA.
Metadata
- Authors
- Gosselin, R. C., Bowyer, A., Favaloro, E. J., Johnsen, J. M., Lippi, G., Marlar, R. A., Neeves, K., & Rollins‐Raval, M. A.
- Affiliations
- UC Davis Health (US)
- Royal Hallamshire Hospital (GB)
- Westmead Hospital (AU)
- University of Washington (US)
- University of Verona (IT)
- University of New Mexico (US)
- University of Colorado Anschutz (US)
- Corresponding author
- Gosselin, Robert C.
- ORCID
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2021-11
- Volume
- 19
- Issue
- 11
- Pages
- 2857-2861
- ISSN
- 1538-7836 (ISSN-L)
- PMC
- PMC9290683
- OpenAlex
- W3197467153
- Cited by
- 25
- References
- 15
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 1
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- UNM’s Digital Repository (University of New Mexico) (submittedVersion)
- Charles Sturt University Research Output (CRO) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Hematology › Blood properties and coagulation
- Keywords
- coagulation tests, hemostasis testing, supply shortages
- MeSH terms
- Sodium Citrate, Anticoagulants, Blood Coagulation, Blood Coagulation Tests, Blood Specimen Collection, Hemostasis, Humans
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