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Cited by 66

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Efficacy and safety of magnesium isoglycyrrhizinate injection in patients with acute drug‐induced liver injury: A phase II trial

Wang, Yongfeng, Wang, Zhenghua, Gao, Mengqiu, Zhong, Haijun, Chen, Chengwei, Yao, Yang, Zhang, Zhongshun, Zhang, Xia, Li, Fujian, Zhang, Jianzhong, Gu, Hong‐Mei, Chen, Yingxuan, Tang, Jieting, Zhong, Wei, Zeng, Minde, Mao, Yimin·2019·Liver International
DOI 10.1111/liv.14204
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Abstract

Background: Drug‐induced liver injury (DILI) is the most common reason for a drug to be withdrawn from the market. Apart from stopping the offending drug, no regimens are available for treating idiosyncratic DILI in clinical practice. Methods: We carried out a randomized, double‐blind, multidoses, active drug controlled, multicentre phase II trial to assess the safety and efficacy of the study drug, magnesium isoglycyrrhizinate (MgIG), as compared to tiopronin, a standard therapy for DILI in China. The primary outcome was the proportion of alanine aminotransferase (ALT) normalization at week 4 after study drug administration. Logistic regression was used to examine the odds of ALT normalization between low dose (Group A) and high dose (Group B) vs active control (Group C). Results: One hundred and seventy‐four eligible subjects were randomized and enrolled into three groups: 59 in group A, 56 in group B and 59 in group C. It was shown that group A and group B lowered ALT level even at early stage of study drug administration; when compared with Group C (61.02%), the proportions of ALT normalization at week 4 were significantly greater in Group A (84.75%, P = .0029) and Group B (85.71%, P = .0037) respectively. The results from the univariate logistic model showed that the odds of ALT normalized among subjects in Group A were about 3.6 times greater (OR = 3.55, 95% CI: 1.47‐8.57, P = .0049) than subjects in Group C. Similar effect was observed among subjects in Group B (OR = 3.83, 95% CI: 1.54‐9.55, P = .0039). Conclusions: This trial provided preliminary evidence that MgIG is an effective and safe treatment for patients with acute DILI.

Overview

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Registry

Crossref · 10.1111/liv.14204

Cites

1 of 1 references verified0 citation errors · 0 not checkable

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  • Magnesium isoglycyrrhizinate has been shown to promote ALT and AST normalization in patients with acute DILI when administered intravenously 200 mg/day for at least 2 weeks.

    “It has been shown to promote ALT and AST normalization in patients with acute DILI when administrated intravenously 200 mg/ day for at least 2 weeks [194].”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [194]

Citations

Cites

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Research works printed but not linked: 16

  1. Friedman SE, 2003, Current diagnosis & treatment in gastroenterology, 664
  2. 10.1002/hep.510260319 · DOI · Paper page
  3. 10.1016/j.jhep.2010.04.029 · DOI
  4. 10.1038/ajg.2014.131 · DOI · Paper page
  5. 10.1136/gut.2008.163675 · DOI
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  7. 10.1186/s12906-015-0861-7 · DOI
  8. 10.1212/WNL.56.10.1405 · DOI
  9. Giordano C, 2014, An update on treatment of drug‐induced liver injury, J Clin Transl Hepatol, 2, 74
  10. 10.1016/0166-3542(96)00942-4 · DOI
  11. 10.1007/s10753-015-0140-2 · DOI
  12. Yan Y, 2015, Magnesium isoglycyrrhizinate prevention of chemotherapy‐induced liver damage during initial treatment of patients with gastrointestinal tumors, Zhonghua Gan Zang Bing Za Zhi, 23, 204
  13. 10.1053/j.gastro.2009.06.006 · DOI · Paper page
  14. 10.1002/hep.26001 · DOI · Paper page
  15. Huang X, 2014, Magnesium isoglycyrrhizinate protects hepatic L02 cells from ischemia/reperfusion induced injury, Int J Clin Exp Pathol, 7, 4755
  16. 10.1007/s10753-015-0140-2 · DOI

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Metadata

Authors
Wang, Y., Wang, Z., Gao, M., Zhong, H., Chen, C., Yao, Y., Zhang, Z., Zhang, X., Li, F., Zhang, J., Gu, H., Chen, Y., Tang, J., Zhong, W., Zeng, M., & Mao, Y.
Venue
Liver International
Publisher
Wiley
Published
2019-08-21
Volume
39
Issue
11
Pages
2102-2111
ISSN
  • 1478-3223
  • 1478-3231
DOI
10.1111/liv.14204
Cited by
66
References
1
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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