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NAFLD is related to Post‐prandial Triglyceride‐enrichment of HDL Particles in Association with Endothelial and HDL Dysfunction
Open accessAbstract
NAFLD is closely related with the metabolic syndrome (MetS) and increased risk of cardiovascular disease. Liver fat associates with post‐prandial hypertriglyceridemia, potentially contributing to triglyceride‐enrichment of high‐density lipoproteins (HDL‐TG), and subsequent HDL dysfunction. We assessed liver fat by MR spectroscopy, and its association with HDL physiochemical properties, and endothelial function, measured as flow‐mediated dilation (FMD), before and following three consecutive meals, in 36 men with type 2 diabetes mellitus (T2DM), with the MetS, and controls. Plasma triglycerides increased significantly following the meals ( P < .001). Fasting HDL‐TG was highest in T2DM, relative to MetS and controls ( P = .002), and increased post‐prandially in all groups ( P < .001). HDL function was negatively associated with HDL‐TG following three meals ( r = −.32, P <.05). Liver fat associated with HDL‐TG after three meals ( r = .65, P < .001). HDL‐TG was independently associated with FMD following three consecutive meals ( r = −.477, P = .003). We conclude liver fat is associated with post‐prandial HDL‐TG enrichment which was closely related with endothelial and HDL dysfunction.
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Several studies have provided evidence that the vascular effects of HDL are variable and hardly correlate with HDL-C concentrations in the plasma.
“Secondly, several studies also have provided evidence that the vascular effects of HDL are variable and hardly correlate with HDL-C concentrations in the plasma.”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [79]
The Background (page not provided) reports that HDL’s anti-atherogenic properties can change with triglyceride enrichment, potentially affecting endothelial protection. The Results (page not provided) associate endothelial function with HDL triglyceride enrichment. Neither passage establishes that HDL’s vascular effects hardly correlate with plasma HDL-C concentrations. (LLM, conf=0.83)
Experimental — accuracy not yet measuredIn patients with diabetes mellitus, coronary disease, chronic renal insufficiency, NAFLD, cardiovascular risk factors and disorders, the function of HDL is impaired.
“In patients with diabetes mellitus, coronary disease, chronic renal insufficiency, NAFLD, cardiovascular risk factors and disorders, the function of HDL is impaired [78, 79].”
From Comparisons of the effects of different flaxseed products consumption on lipid profiles, inflammatory cytokines and anthropometric indices in patients with dyslipidemia related diseases: systematic review and a dose-response meta-analysis of randomized controlled trials (2021) · cites this paper as [79]
The Background reports evidence of functionally defective HDL in NAFLD, and the Results link post-prandial HDL dysfunction to triglyceride enrichment in a study of men with type 2 diabetes, metabolic syndrome, and controls (page numbers unavailable). The paper does not establish impaired HDL function in patients with coronary disease or chronic renal insufficiency, nor across the full range of cardiovascular risk factors and disorders named in the claim. (LLM, conf=0.88)
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References 16 · Cited by 41
Metadata
- Authors
- Verwer, B. J., Scheffer, P. G., Vermue, R. P., Pouwels, P. J., Diamant, M., & Tushuizen, M. E.
- Affiliations
- Leiden University Medical Center (NL)
- Amsterdam University Medical Centers (NL)
- Department of Internal Medicine Amsterdam University Medical Centre Amsterdam The Netherlands
- Corresponding author
- Tushuizen, Maarten E.
- Venue
- Liver International
- Publisher
- Wiley
- Published
- 2020-07-25
- Volume
- 40
- Issue
- 10
- Pages
- 2439-2444
- ISSN
- 0106-9543 (ISSN-L)
- 1478-3223
- 1478-3231
- PMC
- PMC7540355
- OpenAlex
- W3040922499
- Cited by
- 41
- References
- 16
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 7 · 2022: 6 · 2021: 13
- FWCI
- 4.66
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Liver International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Leiden Repository (Leiden University) (submittedVersion, cc-by)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- non-alcoholic fatty liver disease, postprandial hypertriglyceridemia, endothelial dysfunction, flow-mediated dilation, HDL dysfunction, liver fat, metabolic syndrome, type 2 diabetes, MR spectroscopy, cardiovascular risk
- MeSH terms
- Diabetes Mellitus, Type 2, Humans, Lipoproteins, HDL, Cholesterol, HDL, Male, Triglycerides, Postprandial Period, Non-alcoholic Fatty Liver Disease
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