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Effects of the herbal preparation STW 5‐II on in vitro muscle activity in the guinea pig stomach

Schemann, Michael, Landmann, Martina, Kelber, O., Ammar, Ramy M., Krueger, Dagmar, Michel, K.·2021·Neurogastroenterology & Motility
DOI 10.1111/nmo.13984
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Abstract

Background: STW 5 is a combination of nine medicinal herbal extracts and used to treat functional gastrointestinal disorders including functional dyspepsia. It has a region‐specific effect by relaxing the proximal and contracting the distal stomach. The research combination STW 5‐II (Iberogast® Advance) lacks three herbal extracts but seems clinically as effective as STW 5. However, the action of STW 5‐II on gastric motility is unknown. Methods: In vitro circular and longitudinal muscle tone and contractility were recorded from guinea pig gastric fundus and antrum with isometric force transducers. Key Results: STW 5‐II decreased concentration‐dependently (64‐512 µg/ml) the tone of circular and longitudinal muscle strips from the fundus. In contrast, STW 5‐II increased concentration‐dependently contraction amplitude in antral circular and longitudinal muscle. The effects were region‐dependent but comparable in the two muscle layers. Application of 512 µg STW 5 or STW 5‐II revealed comparable effects in the fundus and antrum circular and longitudinal muscle strips. Conclusions and Interferences: STW 5‐II had a region‐specific effect and relaxed the proximal stomach but increased the contractility in the antrum. It was as effective as STW 5 which may explain its comparable clinical effects in treating functional dyspepsia. Impaired accommodation may be normalized through relaxation of the fundus, while the motility‐promoting effects leading to an increase in antral motility may activate the gastric pump.

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Research works printed but not linked: 21

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Metadata

Authors
Schemann, M., Landmann, M., Kelber, O., Ammar, R. M., Krueger, D., & Michel, K.
Affiliations
  • Human Biology Technical University Munich Freising Germany
  • Bayer Consumer Health Steigerwald Arzneimittelwerk GmbH Darmstadt Germany
ORCID
Schemann, Michael
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2020-09-16
Volume
33
Issue
2
ISSN
  • 1350-1925
  • 1365-2982
DOI
10.1111/nmo.13984
Cited by
17
References
0
Language
en
Licence
creativecommons.org/licenses/by-nc/3.0/ (vor)

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