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Safety of allergen‐specific immunotherapy in children
Open accessAbstract
Allergic respiratory diseases, such as asthma and allergic rhinitis, are global health issues and have had an increasing prevalence in the last decades. Allergen‐specific immunotherapy (AIT) is the only curative treatment for allergic rhinitis and asthma, as it has a disease‐modifying effect. AIT is generally administered by two routes: subcutaneous (SCIT) and sublingual immunotherapy (SLIT). Local side effects are common, but usually well‐tolerated and self‐limited. However, systemic side effects are rare, and associated with uncontrolled asthma and bronchial obstruction, or related to errors in administration. Physicians should constantly assess potential risk factors for not only reporting systemic reactions and fatalities but also implementing other therapies to improve AIT safety. This paper highlights recent evidence on local and systemic reactions related to SCIT and SLIT in children.
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41% of cat-allergic patients receiving subcutaneous cat allergen extracts experienced severe systemic reactions.
“Nevertheless, ASIT is associated with certain risks: 41% of cat-allergic patients receiving subcutaneous cat allergen extracts experienced severe systemic reactions [164].”
From Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control (2025) · cites this paper as [164]
The Background section on subcutaneous allergen immunotherapy reports general rates of systemic reactions, but does not discuss cat-allergic patients or subcutaneous cat allergen extracts. Searches for the cat-specific treatment and 41% figure found no passage addressing the claimed rate; the general rates do not establish or refute a rate for that subgroup. (LLM, conf=0.76)
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Advance in Managing Indoor Cat Allergen Proteins: Molecular Insights, Detection, and Control
Jiang, Y., Tian, X., Fu, X., Ma, B., Wang, Z., Han, B., Tao, H., Wang, J., & Wang, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262210913 · Cited by 3
“Nevertheless, ASIT is associated with certain risks: 41% of cat-allergic patients receiving subcutaneous cat allergen extracts experienced severe systemic reactions [164].”
Metadata
- Authors
- De Filippo, M., Votto, M., Caminiti, L., Panasiti, I., Carella, F., De Castro, G., Landi, M., Olcese, R., Vernich, M., Marseglia, G. L., Ciprandi, G., & Barberi, S.
- Affiliations
- Pediatric Clinic Fondazione IRCCS Policlinico San Matteo Pavia Italy
- University of Pavia (IT)
- University of Messina (IT)
- Ospedale Pediatrico Giovanni XXIII (IT)
- Department of Pediatrics Sapienza University of Rome Rome Italy
- Istituto di Biomedicina e di Immunologia Molecolare Alberto Monroy (IT)
- Istituto Giannina Gaslini (IT)
- Aziende Socio Sanitaria Territoriale Rhodense (IT)
- Corresponding author
- Ciprandi, Giorgio
- ORCID
- Venue
- Pediatric Allergy and Immunology
- Publisher
- Wiley
- Published
- 2022-01
- Volume
- 33
- Issue
- S27
- Pages
- 27-30
- ISSN
- 0905-6157 (ISSN-L)
- 1399-3038
- PMC
- PMC9544714
- OpenAlex
- W4210795473
- Cited by
- 28
- References
- 0
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 5 · 2023: 3 · 2022: 5
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Pediatric Allergy and Immunology (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Keywords
- allergen immunotherapy, immunotherapy safety, subcutaneous immunotherapy, sublingual immunotherapy, allergic asthma, allergic rhinitis, local adverse reactions, systemic side effects, children, risk factors
- MeSH terms
- Allergens, Asthma, Child, Desensitization, Immunologic, Humans, Injections, Subcutaneous, Sublingual Immunotherapy, Rhinitis, Allergic
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