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Oxidative stress markers are not associated with outcomes after pediatric heart surgery
Abstract
Summary: Objectives: To investigate whether perioperative serum levels of oxidative stress markers, thiobarbituric acid reactive substances (TBARS), and carbonyl moieties are associated with outcomes in children after heart surgery. Background: Oxidative stress markers are increased following heart surgery with cardiopulmonary bypass (CPB) and can play a role in ischemia–reperfusion injury, but its associations with myocardial dysfunction, low cardiac output syndrome (LCOS), and outcomes are not proven. Methods: In a retrospective secondary analysis of a cohort study comprising 55 children (median age, 109 [2–611] days), we compared pre‐, intra‐ and postoperative serum levels of TBARS and carbonyl moieties among patients with and without postoperative LCOS, cyanotic and acyanotic congenital heart disease (CHD), and survivors and nonsurvivors. We also assessed the independent effect of TBARS and carbonyl moieties peak levels on the mortality‐adjusted hospital length of stay (a LOS). Results: Patients who developed postoperative LCOS (n = 36) were significantly younger, more frequently cyanotic, more severely ill, and underwent more complex procedures with longer CPB. However, TBARS and carbonyl moieties serum levels did not change significantly over time. Moreover, they were not significantly different in patients with or without LCOS, cyanotic and acyanotic CHD, or survivors and nonsurvivors. There was a significant correlation between TBARS and tumor necrosis factor alpha (TNF‐α) peak serum levels. Neither TBARS nor carbonyl moieties peak serum levels were independently associated with a LOS. Conclusions: In conclusion, oxidative stress markers TBARS and carbonyl moieties were not associated with the development of LCOS, the a LOS, or mortality in children after heart surgery with CPB.
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“Several therapies have been evaluated for their effect on LCOS and compared in meta-analyses, however LCOS definitions differ among studies varying from the temporary use of a single vasoactive agent to counteract “stunning” to the requirement of mechanical support (15, 16).”
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Schoonen, A., van Klei, W. A., van Wolfswinkel, L., & van Loon, K. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.926957 · Cited by 74
“Several therapies have been evaluated for their effect on LCOS and compared in meta-analyses, however LCOS definitions differ among studies varying from the temporary use of a single vasoactive agent to counteract “stunning” to the requirement of mechanical support (15, 16).”
Background
Metadata
- Authors
- Manso, P. H., Carmona, F., Dal‐Pizzol, F., Petronilho, F., Cardoso, F., Castro, M., & Carlotti, A. P. C. P.
- Affiliations
- Universidade de São Paulo (BR)
- Division of Pediatric Critical Care Medicine Department of Pediatrics, Faculty of Medicine of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil
- Laboratory of Experimental Pathophysiology University of Southern Santa Catarina Criciúma Santa Catarina Brazil
- Division of Endocrinology Department of Internal Medicine, Faculty of Medicine of Ribeirão Preto, University of São Paulo Ribeirão Preto São Paulo Brazil
- Corresponding author
- Manso, Paulo H.
- Venue
- Pediatric Anesthesia
- Publisher
- Wiley
- Published
- 2012-10-06
- Volume
- 23
- Issue
- 2
- Pages
- 188-194
- ISSN
- 1155-5645 (ISSN-L)
- 1460-9592
- OpenAlex
- W1991473962
- Cited by
- 25
- References
- 2
- Citations by year
- 2024: 2 · 2023: 4 · 2022: 4 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Anesthesia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cardiac and Coronary Surgery Techniques
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Congenital Heart Disease Studies
- Health Sciences › Medicine › Surgery › Transplantation: Methods and Outcomes
- Keywords
- oxidative stress biomarkers, TBARS, cardiopulmonary bypass, pediatric cardiac surgery, low cardiac output syndrome, ischemia-reperfusion injury, congenital heart disease, TNF-α, length of hospital stay, postoperative mortality
- MeSH terms
- Anesthesia, Cardiac Output, Low, Cardiopulmonary Bypass, Cyanosis, Female, Heart Defects, Congenital, Cardiac Surgical Procedures, Humans, Infant, Infant, Newborn, Length of Stay, Male, Postoperative Complications, Retrospective Studies, Cohort Studies, Biomarkers, Myocardial Reperfusion Injury, Proportional Hazards Models, Treatment Outcome, Hospital Mortality, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Protein Carbonylation
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