The DOI matches its Crossref record.
Large‐scale production of pharmaceutical proteins in plant cell culture—the protalix experience
Open accessAbstract
Summary: Protalix Biotherapeutics develops recombinant human proteins and produces them in plant cell culture. Taliglucerase alfa has been the first biotherapeutic expressed in plant cells to be approved by regulatory authorities around the world. Other therapeutic proteins are being developed and are currently at various stages of the pipeline. This review summarizes the major milestones reached by Protalix Biotherapeutics to enable the development of these biotherapeutics, including platform establishment, cell line selection, manufacturing process and good manufacturing practice principles to consider for the process. Examples of the various products currently being developed are also presented.
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Citations
Cited by
Progress in biopharmaceutical development
Kesik‐Brodacka, M. (2018) · Biotechnology and Applied Biochemistry · doi:10.1002/bab.1617 · Cited by 353
Recent Applications of Plant Cell Culture Technology in Cosmetics and Foods
Krasteva, G., Georgiev, V., & Pavlov, A. (2021) · Engineering in Life Sciences · doi:10.1002/elsc.202000078 · Cited by 116
Metadata
- Authors
- Tekoah, Y., Shulman, A., Kizhner, T., Ruderfer, I., Fux, L., Nataf, Y., Bartfeld, D., Ariel, T., Gingis–Velitski, S., Hanania, U., & Shaaltiel, Y.
- Venue
- Plant Biotechnology Journal
- Publisher
- Wiley
- Published
- 2015-06-23
- Volume
- 13
- Issue
- 8
- Pages
- 1199-1208
- ISSN
- 1467-7644 (ISSN-L)
- 1467-7652
- OpenAlex
- W2166836758
- Cited by
- 193
- References
- 0
- FWCI
- 11.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Large‐scale production of pharmaceutical proteins in plant cell culture—the protalix experience. https://app.cochat.ai/papers/10.1111/pbi.12428
- The paper
- Tekoah, Y., Shulman, A., Kizhner, T., Ruderfer, I., Fux, L., Nataf, Y., Bartfeld, D., Ariel, T., Gingis–Velitski, S., Hanania, U., & Shaaltiel, Y. (2015). Large‐scale production of pharmaceutical proteins in plant cell culture—the protalix experience. Plant Biotechnology Journal. https://doi.org/10.1111/pbi.12428
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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