Gaps in the elimination of congenital syphilis in a tertiary care center in Thailand
Abstract
Background The World Health Organization has set a goal to eliminate mother-to-child transmission of syphilis to a target of Methods A retrospective chart review was conducted in a tertiary care center in Bangkok, Thailand. The study included all pregnant women with positive syphilis serology and their infants. All congenital syphilis cases were categorized according to Centers for Disease Control criteria. Results From 2013 to 2017, 69 syphilis-infected pregnant women were included, with 30 congenital syphilis cases. The rate of congenital syphilis was 115 cases (95% CI 78-164) per 100 000 live births. The median (interquartile range) maternal age was 21 (18-32) years and 12 (17%) women had human immunodeficiency virus co-infection. Regarding maternal treatment, 28 (41%) women had inadequate treatment due to 13 cases (19%) of late or no antenatal care, six cases (8%) of recent infection near delivery, five cases (7%) of failure of treatment provision, and four (6%) others. There were three syphilitic stillbirths who were prematurely born to untreated pregnant women and 67 live births (one set of twins) of which 27 met definitions of probable congenital syphilis. They received complete treatment with penicillin and had non-reactive rapid plasma reagin within the first 6 months of life, with the exception of one who had non-reactive rapid plasma reagin at the age of 7 months. Conclusions Congenital syphilis remains a problem in our setting. Nearly half of pregnant women who ha…
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The incidence of congenital syphilis rose to 28% if diagnosed and treated in the second trimester.
“The incidence rose to 28% if diagnosed and treated in the second trimester, and reached 80% if diagnosed and treated in the third trimester.2,5,14”
From Fetal Outcome in Pregnancy Infected Syphilis Treated with Penicillin G: A Systematic Review: Analysis (2025) · cites this paper as [14]
The incidence of congenital syphilis reached 80% if diagnosed and treated in the third trimester.
“The incidence rose to 28% if diagnosed and treated in the second trimester, and reached 80% if diagnosed and treated in the third trimester.2,5,14”
From Fetal Outcome in Pregnancy Infected Syphilis Treated with Penicillin G: A Systematic Review: Analysis (2025) · cites this paper as [14]
Cites
Korenromp, E. L., Rowley, J., Alonso, M., Mello, M. B., Wijesooriya, N. S., Mahiané, S. G., Ishikawa, N., Le, L.-V., Newman-Owiredu, M., Nagelkerke, N., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0211720 · Cited by 478 · see citing works
Elimination of mother-to-child transmission of HIV and syphilis in Cuba and Thailand
Ishikawa, N., Newman, L., Taylor, M., Essajee, S., Pendse, R., & Ghidinelli, M. (2016) · Bulletin of the World Health Organization · doi:10.2471/blt.16.185033 · Cited by 43 · see citing works
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Nathaniel, J., & Simanjuntak, T. P. (2025) · Cermin Dunia Kedokteran · doi:10.55175/cdk.v52i1.1297
- Authors
- Anugulruengkitt, S., Yodkitudomying, C., Sirisabya, A., Chitsinchayakul, T., Jantarabenjakul, W., Chaithongwongwatthana, S., & Puthanakit, T.
- Affiliations
- Chulalongkorn University (TH)
- Center of Excellence for Pediatric Infectious Diseases and Vaccines Chulalongkorn Bangkok Thailand
- Corresponding author
- Anugulruengkitt, Suvaporn
- ORCID
- Venue
- Pediatrics International
- Publisher
- Wiley
- Published
- 2020-03
- Volume
- 62
- Issue
- 3
- Pages
- 330-336
- ISSN
- 1328-8067 (ISSN-L)
- 1442-200X
- OpenAlex
- W2997978841
- Cited by
- 9
- References
- 2
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2020: 1
- FWCI
- 0.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatrics International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Syphilis Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Historical Medical Research and Treatments
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- congenital syphilis, mother-to-child transmission, maternal syphilis, prenatal care, treatment gap, HIV coinfection, penicillin therapy, RPR, stillbirth, Thailand
- MeSH terms
- Adolescent, Adult, Anti-Bacterial Agents, Female, Humans, Infant, Newborn, Penicillins, Pregnancy, Pregnancy Complications, Infectious, Pregnancy Outcome, Prenatal Care, Retrospective Studies, Syphilis, Syphilis, Congenital, Thailand, Infectious Disease Transmission, Vertical, Young Adult, Tertiary Care Centers
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