Self-reported regular alcohol consumption in adolescents and emerging adults with type 1 diabetes: A neglected risk factor for diabetic ketoacidosis? Multicenter analysis of 29 630 patients from the DPV registry: HERMANN et al .
Open accessAbstract
Background The risk of hypoglycemia increases after alcohol consumption in patients with type 1 diabetes. This study aimed to investigate the association between metabolic control and self-reported alcohol consumption in young patients with type 1 diabetes. Materials and Methods N = 29 630 patients with type 1 diabetes aged 12 to <30 years (median age 17.0 [14.9, 18.3] years, duration of diabetes 6.8 [3.3, 10.9] years, 53% male) from the German/Austrian DPV registry were analyzed. Patients were categorized into abstainers, low-risk drinkers, and at-risk drinkers. BMI, HbA1c, and rates of severe hypoglycemia (SH) and diabetic ketoacidosis (DKA) were compared between alcohol consumption groups using multivariable hierarchical regression models. The association between alcohol use and smoking status was assessed using χ 2 test. Results Overall, 10.8% of the patients reported regular alcohol consumption. Proportion of alcohol use as well as the amount of alcohol consumed increased with age and were higher in males than in females (all P < .05). Patients with Turkish migration background reported less alcohol consumption. HbA1c, SH rate, and DKA rate (adjusted for age, gender, duration of diabetes, therapy) were significantly lower in abstainers than in patients drinking alcohol (all P < .05). Smoking status was significantly associated with alcohol consumption (P < .001). Conclusion Self-reported alcohol consumption is likely to be underreported when collected in face-to-face settings such as doctors’ visits. Nevertheless, our data revealed a significant association between higher alcohol consumption and worse glycemic control, in particular higher DKA rates. Information about alcohol-induced complications is of great importance in diabetes education in young people with type 1 diabetes.
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Increased alcohol consumption is associated with a higher risk of DKA and level 3 hypoglycemia.
“Increased alcohol consumption is associated with a higher risk of DKA and level 3 hypoglycemia (135).”
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Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699 · see citing works
Ehrmann, D., Kulzer, B., Roos, T., Haak, T., Al-Khatib, M., & Hermanns, N. (2020) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(20)30042-5 · Cited by 141 · see citing works
- Authors
- Hermann, J. M., Meusers, M., Bachran, R., Kuhnle-Krahl, U., Jorch, N., Hofer, S. E., Holl, R. W., & initiative, F. T. D.
- Affiliations
- Universität Ulm (DE)
- Gemeinschaftskrankenhaus Herdecke (DE)
- Pediatric Practice; Oberhausen Germany
- Department of Pediatric Endocrinology and Diabetology; Diabetes practice; Gauting Germany
- Evangelisches Krankenhaus Bielefeld (DE)
- Innsbruck Medical University (AT)
- Corresponding author
- Hermann, Julia M.
- Venue
- Pediatric Diabetes
- Publisher
- Wiley
- Published
- 2017-02-01
- Volume
- 18
- Issue
- 8
- Pages
- 817-823
- ISSN
- 1399-543X (ISSN-L)
- OpenAlex
- W2583249047
- Cited by
- 49
- References
- 3
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 4 · 2018: 6 · 2017: 4 · 2016: 1
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Pediatric Diabetes (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Foundation for the Study of Diabetes
- Bundesministerium für Bildung und Forschung (FKZ 01GI1106)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- type 1 diabetes, alcohol consumption, diabetic ketoacidosis, adolescents, emerging adults, glycemic control, HbA1c, severe hypoglycemia, smoking, diabetes education, DPV registry
- MeSH terms
- Adolescent, Adult, Alcohol Drinking, Austria, Child, Diabetes Mellitus, Type 1, Female, Germany, Glycated Hemoglobin, Humans, Hypoglycemia, Male, Registries, Smoking, Body Mass Index, Diabetic Ketoacidosis, Young Adult
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