Antibody‐mediated control of T rypanosoma vivax infection fails in the absence of tumour necrosis factor
Open accessAbstract
Trypanosoma vivax causes a wasting disease affecting livestock breeding and agriculture in developing countries of sub-Sahara Africa and South America. Being an extracellular parasite, control of T. vivax has been proposed to be mediated by host antibodies. However, the use of a comparative infection model of wild-type (WT) and tumour necrosis factor (TNF) knockout (TNF(-/-) ) mice shows that the latter is unable to control first-peak parasitaemia, despite the presence of specific antitrypanosome antibodies. In contrast, WT mice parasitaemia peak control coincides with a combined early onset of TNF production and induction of specific antibodies. TNF is mainly produced by liver-associated monocytes and neutrophils. In this study, no other correlation between cellular immunomodulations and peak parasitaemia control was observed, underscoring the importance of the role of TNF in the control of T. vivax infections.
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There is a difference in trypanosome-specific antiparasite antibody secreting cells in spleen and B cell activation between trypanotolerant and trypanosusceptible cattle.
“There is a difference in trypanosome-specific antiparasite Ab secreting cells in spleen and B cell activation between trypanotolerant and trypanosusceptible cattle (La Greca et al., 2014; Mamoudou et al., 2016; Morrison et al., 2016).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as La Greca et al., 2014
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References 25 · Cited by 20
- Authors
- La Greca, F., Haynes, C., Stijlemans, B., De Trez, C., & Magez, S.
- Affiliations
- Research Unit of Cellular and Molecular Immunology Vrije Universiteit Brussel Brussels Belgium
- Vrije Universiteit Brussel (BE)
- Corresponding author
- Magez, S.
- Venue
- Parasite Immunology
- Publisher
- Wiley
- Published
- 2014-05-15
- Volume
- 36
- Issue
- 6
- Pages
- 271-276
- ISSN
- 0141-9838 (ISSN-L)
- 1365-3024
- OpenAlex
- W2045861445
- Cited by
- 20
- References
- 25
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2
- FWCI
- 2.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Parasite Immunology (publishedVersion)
- PubMed (publishedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Funders
- Fonds Wetenschappelijk Onderzoek
- Topics
- Health Sciences › Medicine › Epidemiology › Trypanosoma species research and implications
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- Trypanosoma vivax, TNF-α, humoral immunity, neutrophils, host-parasite interactions, extracellular parasites
- MeSH terms
- Animals, Antibodies, Female, Mice, Inbred AKR, Mice, Inbred C57BL, Trypanosomiasis, African, Tumor Necrosis Factor-alpha, Trypanosoma vivax, Parasitemia, Mice
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