The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats
Abstract
Multiwalled carbon nanotubes ( MWCNTs ) have attracted public attention not only for their potential applications in engineering and materials science but also for possible environmental risks. MWCNTs share similar properties with asbestos, a definite human carcinogen causing malignant mesothelioma ( MM ), in that they are both biopersistent thin fibers with a high aspect ratio. Certain types of MWCNTs do induce MM in animal experiments. Though there are many different types of MWCNTs awaiting use in industry, there is little evidence about what types of MWCNTs present a high risk for MM in vivo . We have previously shown that the diameter of MWCNTs is one of the critical factors for mesothelial injury, which eventually leads to MM . Because of the extensive commercial use of MWCNTs , the properties of MWCNTs that determine carcinogenic activity should be clarified. Here we report that a high dose (10 mg) of a tangled form of pristine MWCNT (with a diameter of 15 nm) did not induce MM after intraperitoneal administration in rats, which were followed for up to 3 years after injection. This observation strengthens our previous finding that the rigidity, diameter, length and surface properties of MWCNTs are important factors in MM induction in vivo .
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“our previous findings using various carbon nanotubes of different diameters indicated that the degree of fibrosis and iron deposits observed in subacute experiments is predictive of subsequent mesothelial carcinogenesis.23, 30”
From Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis (2016) · cites this paper as [30]
In the citing paper
“Because inflammogenicity of a fiber is proportionally associated with subsequent mesothelial carcinogenesis”
From Dual preventive benefits of iron elimination by desferal in asbestos‐induced mesothelial carcinogenesis (2016) · cites this paper as [30]
Citations
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Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma
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Rittinghausen, S., Hackbarth, A., Creutzenberg, O., Ernst, H., Heinrich, U., Leonhardt, A., & Schaudien, D. (2014) · Particle and Fibre Toxicology · doi:10.1186/s12989-014-0059-z · Cited by 193
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Self-citationToyokuni, S. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.10.401 · Cited by 96
Self-citationIron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis
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Metadata
- Authors
- Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Miyata, Y., Shinohara, H., & Toyokuni, S.
- Affiliations
- Department of Pathology and Biological Responses Nagoya University Graduate School of Medicine
- Department of Chemistry and Institute for Advanced Research Nagoya University Nagoya Japan
- Venue
- Pathology International
- Publisher
- Wiley
- Published
- 2013-09
- Volume
- 63
- Issue
- 9
- Pages
- 457-462
- ISSN
- 1320-5463
- 1440-1827
- Cited by
- 48
- References
- 2
- Language
- en
- Funders
- Princess Takamatsu Cancer Research Fund (10-24213)
- Ministry of Health, Labor and Welfare of Japan
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
- MEXT Special Coordination Funds for Promoting Science and Technology Grant
- Japan Society for the Promotion of Science Fellows
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- Nagai, H., Okazaki, Y., Chew, S. H., Misawa, N., Miyata, Y., Shinohara, H., & Toyokuni, S. (2013). Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats. Pathology International. https://doi.org/10.1111/pin.12093
