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Cited by 281

The DOI matches its Crossref record; 241 of the 241 references it cites were found in a registry or an index.

Polymicrobial communities in periodontal disease: Their quasi‐organismal nature and dialogue with the host

Open access
Hajishengallis, George, Lamont, Richard J.·2021·Periodontology 2000
DOI 10.1111/prd.12371
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Abstract

In health, indigenous polymicrobial communities at mucosal surfaces maintain an ecological balance via both inter‐microbial and host‐microbial interactions that promote their own and the host's fitness, while preventing invasion by exogenous pathogens. However, genetic and acquired destabilizing factors (including immune deficiencies, immunoregulatory defects, smoking, diet, obesity, diabetes and other systemic diseases, and aging) may disrupt this homeostatic balance, leading to selective outgrowth of species with the potential for destructive inflammation. This process, known as dysbiosis, underlies the development of periodontitis in susceptible hosts. The pathogenic process is not linear but involves a positive‐feedback loop between dysbiosis and the host inflammatory response. The dysbiotic community is essentially a quasi‐organismal entity, where constituent organisms communicate via sophisticated physical and chemical signals and display functional specialization (eg, accessory pathogens, keystone pathogens, pathobionts), which enables polymicrobial synergy and dictates the community's pathogenic potential or nososymbiocity. In this review, we discuss early and recent studies in support of the polymicrobial synergy and dysbiosis model of periodontal disease pathogenesis. According to this concept, disease is not caused by individual “causative pathogens” but rather by reciprocally reinforced interactions between physically and metabolically integrated polymicrobial communities and a dysregulated host inflammatory response.

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Citations

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Metadata

Authors
Hajishengallis, G., & Lamont, R. J.
Venue
Periodontology 2000
Publisher
Wiley
Published
2021-03-10
Volume
86
Issue
1
Pages
210-230
ISSN
  • 0906-6713 (ISSN-L)
  • 1600-0757
DOI
10.1111/prd.12371
OpenAlex
W3134907435
Cited by
281
References
241
FWCI
34.76
Type
journal article
Language
en
Open access
green

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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