Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults

Lee, Shuen Yee; Fam, Kai Deng; Chia, Kar Ling; Yap, Margaret M. C.; Goh, Jorming; Yeo, Kwee Poo; Yap, Eric P. H.; Chotirmall, Sanjay H.; Lim, Chin Leong

doi:10.1113/ep088351

Age‐related bone loss is associated with FGF21 but not IGFBP1 in healthy adults

What is the central question of this study? Fibroblast growth factor 21 (FGF21) plays important therapeutic roles in metabolic diseases but is associated with bone loss, through insulin‐like growth factor binding protein 1 (IGFBP1), in animals. However, the effect of the FGF21–IGFBP1 axis on age‐…