Dynamin independent mechanism of exo-endocytosis coupling
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Disruption in priming components can directly impair release efficiency, even if the core fusion machinery remains intact.
“This implies that any disruption in these priming components can directly impair release efficiency, even if the core fusion machinery remains intact [28].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [28]
The Figure 1 caption (page not provided) says dynamin depletion reduces the readily releasable vesicle pool and inhibits multivesicular neurotransmission, supporting the general link between disrupted vesicle supply and impaired release. The paper discusses dynamin-dependent endocytosis, not disruption of priming components, and does not establish that the core fusion machinery remains intact or that any priming-component disruption has this effect. (LLM, conf=0.82)
Experimental — accuracy not yet measuredCME typically occurs in the peri-active zone, adjacent to the sites of neurotransmitter release.
“CME typically occurs in the peri-active zone, adjacent to the sites of neurotransmitter release [12,28].”
From Molecular Physiology of the Neuronal Synapse (2026) · cites this paper as [28]
The main text discusses synaptic vesicle recycling and components of clathrin-mediated endocytosis, but does not say where CME typically occurs. Searches for the peri-active zone and for CME’s location relative to release sites found no passage addressing that spatial claim. (LLM, conf=0.75)
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References 5 · Cited by 3
Research works printed but not linked: 5
- Afuwape, O. A. T., Chanaday, N. L., Kasap, M., Monteggia, L. M., & Kavalali, E. T. (2025). Persistence of quantal synaptic vesicle recycling in virtual absence of dynamins. The Journal of Physiology, 603(20), 6161– 6184. 39141823 PMC11825889
- Ferguson, S. M., & De Camilli, P. (2012). Dynamin, a membrane‐remodelling GTPase. Nature Reviews Molecular Cell Biology, 13(2), 75– 88. 22233676 PMC3519936
- Newton, A. J., Kirchhausen, T., & Murthy, V. N. (2006). Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proceedings of the National Academy of Sciences of the United States of America, 103(47), 17955– 17960. 17093049 PMC1693854
- Wu, L. G., & Chan, C. Y. (2024). Membrane transformations of fusion and budding. Nature Communications, 15(1), 21. PMC10761761 38167896
- Xu, J., McNeil, B., Wu, W., Nees, D., Bai, L., & Wu, L. G. (2008). GTP‐independent rapid and slow endocytosis at a central synapse. Nature Neuroscience, 11(1), 45– 53. 18066059
- Authors
- Bandura, J., & Feng, Z.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Feng, Zhong‐Ping
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2024-11-04
- Volume
- 603
- Issue
- 20
- Pages
- 5869-5870
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- PMC
- PMC12559973
- OpenAlex
- W4404028665
- Cited by
- 3
- References
- 5
- Citations by year
- 2026: 2 · 2025: 1
- FWCI
- 0.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Journal of Physiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (PJT‐191824)
- Natural Sciences and Engineering Research Council of Canada (RGPIN‐2022‐04467)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- exocytosis, endocytosis, membrane trafficking
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