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A relation between the chain length of fatty acids and the slowing of gastric emptying
Open accessAbstract
1. Test meals of solutions and suspensions of potassium and sodium salts of a series of saturated fatty acids, from C 2 to C 18, were given to healthy subjects. 2. From the volume of these meals recovered after a fixed interval the relative effectiveness of the salts of the acids in slowing gastric emptying was assessed. 3. On a molar basis the salts of fatty acids from acetic up to decanoic were relatively ineffective in slowing gastric emptying. 4. The salts of fatty acids with 12‐18 carbon atoms were much more effective than those with up to 10 carbon atoms. Myristate was the most effective of the salts. 5. Buffering the test meals with 33 m M sodium citrate increased the effectiveness of the salts in slowing gastric emptying.
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Citations
Cited by
Charman, W. N., Porter, C. J. H., Mithani, S., & Dressman, J. B. (1997) · Journal of Pharmaceutical Sciences · doi:10.1021/js960085v · Cited by 617
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Kalepu, S., Manthina, M., & Padavala, V. (2013) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2013.10.001 · Cited by 494
Ileal brake: a sensible food target for appetite control. A review
Maljaars, P. W. J., Peters, H. P. F., Mela, D. J., & Masclee, A. A. M. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.07.018 · Cited by 451
Gentilcore, D., Chaikomin, R., Jones, K. L., Russo, A., Feinle-Bisset, C., Wishart, J. M., Rayner, C. K., & Horowitz, M. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-2644 · Cited by 351
Vagal afferent responses to fatty acids of different chain length in the rat
Lal, S., Kirkup, A. J., Brunsden, A. M., Thompson, D. G., & Grundy, D. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.4.g907 · Cited by 303
Metadata
- Authors
- Hunt, J. N., & Knox, M. T.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1968-02
- Volume
- 194
- Issue
- 2
- Pages
- 327-336
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2040119336
- Cited by
- 301
- References
- 0
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- green
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- Hunt, J. N., & Knox, M. T. (1968). A relation between the chain length of fatty acids and the slowing of gastric emptying. The Journal of Physiology. https://doi.org/10.1113/jphysiol.1968.sp008411
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
