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Further purification of a polypeptide demonstrating enterogastrone activity
Open accessAbstract
1. The further purification of a polypeptide having potent enterogastrone activity, without CCK—PZ effects, is described. 2. The material was inhibitory when doses of 1·0 μg/kg.hr were administered intravenously. Amino acid analyses demonstrated the absence of proline, a high content of glutamine and a preponderance of lysine over arginine. Tryptic degradation destroys the inhibitory effect of the polypeptide. Further studies must be performed before the physiological status of the polypeptide can be ascertained.
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Cited by
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Müller, T. D., Finan, B., Bloom, S. R., D'Alessio, D., Drucker, D. J., Flatt, P. R., Fritsche, A., Gribble, F., Grill, H. J., Habener, J. F., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2019.09.010 · Cited by 1,868
GLP-1 receptor agonists for individualized treatment of type 2 diabetes mellitus
Meier, J. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.140 · Cited by 1,311
Kieffer, T. J., McIntosh, C. H., & Pederson, R. A. (1995) · Endocrinology · doi:10.1210/endo.136.8.7628397 · Cited by 1,124
Self-citationGIP and GLP-1, the two incretin hormones: Similarities and differences
Seino, Y., Fukushima, M., & Yabe, D. (2010) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00022.x · Cited by 746
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
Metadata
- Authors
- Brown, J. C., Mutt, V., & Pederson, R. A.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1970-07
- Volume
- 209
- Issue
- 1
- Pages
- 57-64
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2102977341
- Cited by
- 276
- References
- 0
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- green
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- Brown, J. C., Mutt, V., & Pederson, R. A. (1970). Further purification of a polypeptide demonstrating enterogastrone activity. The Journal of Physiology. https://doi.org/10.1113/jphysiol.1970.sp009155
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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