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Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ.
Open accessAbstract
1. Nerve fibres containing substance P immunoreactivity were present in the adventitia and the adventitia‐media border of all cat cerebral arteries which were examined. Substance P immunoreactivity was most abundant in cerebral arteries from the rostral portion of the circle of Willis. 2. Substance P effected a dose‐dependent relaxation of feline middle cerebral arteries which had been contracted with prostaglandin F2 alpha. The maximum relaxation (16 +/‐ 0.3 mN) was achieved with substance P at a concentration of 10‐6 M. 3. In cats anaesthetized with alpha‐chloralose, the perivascular microinjection of substance P effected dose‐dependent increases in arteriolar calibre. The maximum increase in calibre (19 +/‐ 3%) was observed following the injection of 10(‐6) M‐substance P.
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Citations
Cited by
The neurobiology of vascular head pain
Moskowitz, M. A. (1984) · Annals of Neurology · doi:10.1002/ana.410160202 · Cited by 905
Uddman, R., Edvinsson, L., Ekman, R., Kingman, T., & McCulloch, J. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90296-4 · Cited by 408
Self-citationCutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat
Duggan, A. W., Hendry, I. A., Morton, C. R., Hutchinson, W. D., & Zhao, Z. Q. (1988) · Brain Research · doi:10.1016/0006-8993(88)90771-8 · Cited by 349
Mayberg, M. R., Zervas, N. T., & Moskowitz, M. A. (1984) · Journal of Comparative Neurology · doi:10.1002/cne.902230105 · Cited by 323
Factors involved in the physiological regulation of the cerebral circulation
Busija, D. W., & Heistad, D. D. (1984) · Reviews of Physiology, Biochemistry and Pharmacology · doi:10.1007/bfb0027696 · Cited by 267
Metadata
- Authors
- Edvinsson, L., McCulloch, J., & Uddman, R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 1981-09
- Volume
- 318
- Issue
- 1
- Pages
- 251-258
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1486930410
- Cited by
- 204
- References
- 0
- FWCI
- 4.84
- Type
- journal article
- Language
- en
- Open access
- green
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- Edvinsson, L., McCulloch, J., & Uddman, R. (1981). Substance P: immunohistochemical localization and effect upon cat pial arteries in vitro and in situ. The Journal of Physiology. https://doi.org/10.1113/jphysiol.1981.sp013862
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
