The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Shaping the excitability of human motor cortex with premotor rTMS
Abstract
Recent studies have shown that low‐frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsal premotor cortex has a lasting influence on the excitability of specific neuronal subpopulations in the ipsilateral primary motor hand area (M1HAND). Here we asked how these premotor to motor interactions are shaped by the intensity and frequency of rTMS and the orientation of the stimulating coil. We confirmed that premotor rTMS at 1 Hz and an intensity of 90% active motor threshold (AMT) produced a lasting decrease in corticospinal excitability probed with single‐pulse TMS over the left M1HAND. Reducing the intensity to 80% AMT increased paired‐pulse excitability at an interstimulus interval (ISI) of 7 ms. Opposite effects occurred if rTMS was given at 5 Hz: at 90% AMT, corticospinal excitability increased; at 80% AMT, paired‐pulse excitability at ISI = 7 ms decreased. No effects were seen if rTMS was applied at the same intensities to prefrontal or primary motor cortices. These findings indicate that the intensity of premotor rTMS determines the net effect of conditioning on distinct populations of neurones in the ipsilateral M1HAND, but it is the frequency of rTMS that determines the direction of the induced change. By selecting the appropriate intensity and frequency, premotor rTMS allows to induce a predictable up‐ or down‐regulation of the excitability in distinct neuronal circuits of human M1HAND.
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Cites
Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation
Chen, R., Classen, J., Gerloff, C., Celnik, P., Wassermann, E. M., Hallett, M., & Cohen, L. G. (1997) · Neurology · doi:10.1212/wnl.48.5.1398 · Cited by 2,128 · cited 2×
“Stimulation for periods of up to 30 min at a frequency of around 1 Hz (referred to as low-frequency rTMS) results in a decrease in excitability that outlasts the stimulation by 30 min or so (Chen et al. 1997; Muellbacher et al. 2000; Fitzgerald et al. 2002; Touge et al. 2001).”
BackgroundMorecraft, R. J., & van Hoesen, G. W. (1993) · Journal of Comparative Neurology · doi:10.1002/cne.903370411 · Cited by 203
Cited by
Lefaucheur, J.-P., André-Obadia, N., Antal, A., Ayache, S. S., Baeken, C., Benninger, D. H., Cantello, R. M., Cincotta, M., de Carvalho, M., De Ridder, D., et al. (2014) · Clinical Neurophysiology · doi:10.1016/j.clinph.2014.05.021 · Cited by 2,119
Self-citationInhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Is there a future for therapeutic use of transcranial magnetic stimulation?
Ridding, M. C., & Rothwell, J. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2169 · Cited by 687
Self-citationPhysiology of repetitive transcranial magnetic stimulation of the human brain
Hoogendam, J. M., Ramakers, G. M. J., & Di Lazzaro, V. (2010) · Brain Stimulation · doi:10.1016/j.brs.2009.10.005 · Cited by 669
Consensus: Motor cortex plasticity protocols
Ziemann, U., Paulus, W., Nitsche, M. A., Pascual-Leone, A., Byblow, W. D., Berardelli, A., Siebner, H. R., Classen, J., Cohen, L. G., & Rothwell, J. C. (2008) · Brain Stimulation · doi:10.1016/j.brs.2008.06.006 · Cited by 639
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Metadata
- Authors
- Rizzo, V., Siebner, H. R., Modugno, N., Pesenti, A., Münchau, A., Gerschlager, W., Webb, R. M., & Rothwell, J. C.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2004-01
- Volume
- 554
- Issue
- 2
- Pages
- 483-495
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W2131060444
- Cited by
- 187
- References
- 2
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rizzo, V., Siebner, H. R., Modugno, N., Pesenti, A., Münchau, A., Gerschlager, W., Webb, R. M., & Rothwell, J. C. (2004). Shaping the excitability of human motor cortex with premotor rTMS. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2003.048777
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