Subunit‐specific mechanisms and proton sensitivity of NMDA receptor channel block

Dravid, Shashank M.; Erreger, Kevin; Yuan, Hongjie; Nicholson, Katherine; Le, Phuong; Lyuboslavsky, Polina; Almonte, Antoine; Murray, Ernest; Mosley, Cara; Barber, Jeremy; French, Adam; Balster, Robert; Murray, Thomas F.; Traynelis, Stephen F.

doi:10.1113/jphysiol.2006.124958

Subunit‐specific mechanisms and proton sensitivity of NMDA receptor channel block

We have compared the potencies of structurally distinct channel blockers at recombinant NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D receptors. The IC 50 values varied with stereochemistry and subunit composition, suggesting that it may be possible to design subunit‐selective channel blockers. For d…