The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Anoctamin/TMEM16 family members are Ca2+‐activated Cl− channels
Open accessAbstract
Ca 2+‐activated Cl− channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up‐regulated in a number of tumours and functional deficiency in others is linked to developmental defects.
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Cites
An Unexpected Role for Ion Channels in Brain Tumor Metastasis
Sontheimer, H. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-308 · Cited by 231
Cited by
Calcium-dependent Phospholipid Scramblase Activity of TMEM16 Protein Family Members
Suzuki, J., Fujii, T., Imao, T., Ishihara, K., Kuba, H., & Nagata, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.457937 · Cited by 371
Lipid scrambling is a general feature of protein insertases
Li, D., Rocha-Roa, C., Schilling, M. A., Reinisch, K. M., & Vanni, S. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2319476121 · Cited by 63
Dauner, K., Möbus, C., Frings, S., & Möhrlen, F. (2013) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.13-11711 · Cited by 35
Anoctamin2 (TMEM16B) forms the Ca2+-activated Cl− channel in the retinal pigment epithelium
Keckeis, S., Reichhart, N., Roubeix, C., & Strauß, O. (2017) · Experimental Eye Research · doi:10.1016/j.exer.2016.12.003 · Cited by 28
Metadata
- Authors
- Hartzell, H. C., Yu, K., Xiao, Q., Chien, L., & Qu, Z.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2009-05-14
- Volume
- 587
- Issue
- 10
- Pages
- 2127-2139
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1926436230
- Cited by
- 261
- References
- 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- green
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- Hartzell, H. C., Yu, K., Xiao, Q., Chien, L., & Qu, Z. (2009). Anoctamin/TMEM16 family members are Ca2+‐activated Cl− channels. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2008.163709
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