Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism

Wu, Min; Dumalska, Iryna; Morozova, Elena; Van Den Pol, Anthony N.; Alreja, Meenakshi

doi:10.1113/jphysiol.2008.166447

Gonadotropin inhibitory hormone inhibits basal forebrain vGluT2‐gonadotropin‐releasing hormone neurons via a direct postsynaptic mechanism

The novel hypothalamic peptides avian gonadotropin inhibitory hormone (GnIH) and its mammalian analogue RFRP‐3, are emerging as key negative regulators of reproductive functions across species. GnIH/RFRP‐3 reduces gonadotropin release and may play an inhibitory role in ovulation and seasonal repr…