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Cited by 74Gastrointestinal motility and disordersIon channel regulation and functionIon Channels and Receptors

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Muscarinic activation of Ca2+‐activated Cl− current in interstitial cells of Cajal

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Zhu, Mei Hong, Sung, In Kyung, Zheng, Haifeng, Sung, Tae Sik, Britton, Fiona C, O’Driscoll, Kate, Koh, Sang Don, Sanders, Kenton M.·2011·The Journal of Physiology
DOI 10.1113/jphysiol.2011.211094PMC PMC3208225
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Abstract

Interstitial cells of Cajal (ICC) provide pacemaker activity and functional bridges between enteric motor nerve terminals and gastrointestinal smooth muscle cells. The ionic conductance(s) in ICC that are activated by excitatory neural inputs are unknown. Transgenic mice (Kit(copGFP/+)) with constitutive expression of a bright green fluorescent protein were used to investigate cellular responses of ICC to cholinergic stimulation. ICC displayed spontaneous transient inward currents (STICs) under voltage clamp that corresponded to spontaneous transient depolarizations (STDs) under current clamp. STICs reversed at 0 mV when E(Cl) = 0 mV and at -40 mV when E(Cl) was -40 mV, suggesting the STICs were due to a chloride conductance. Carbachol (CCh, 100 nm and 1 μm) induced a sustained inward current (depolarization in current clamp) and increased the amplitude and frequency of STICs and STDs. CCh responses were blocked by atropine (10 μm) or 4-DAMP (100 nm), an M(3) receptor antagonist. STDs were blocked by niflumic acid and 5-nitro-2-(3-phenylpropylamino)-benzoic acid (both 100 μm), and CCh had no effect in the presence of these drugs. The responses of intact circular muscles to CCh and stimulation of intrinsic excitatory nerves by electrical field stimulation (EFS) were also compared. CCh (1 μm) caused atropine-sensitive depolarization and increased the maximum depolarization of slow waves. Similar atropine-sensitive responses were elicited by stimulation of intrinsic excitatory n…

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  • Acetylcholine is active at excitatory enteric motoneuron synapses.

    “Another CNS active neurotransmitter, acetylcholine, is active at excitatory enteric motoneuron synapses (Zhu et al., 2011).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Zhu et al., 2011

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Metadata

Authors
Zhu, M. H., Sung, I. K., Zheng, H., Sung, T. S., Britton, F. C., O’Driscoll, K., Koh, S. D., & Sanders, K. M.
Affiliations
University of Nevada, Reno (US)
Corresponding author
Sanders, Kenton M.
ORCID
Venue
The Journal of Physiology
Publisher
Wiley
Published
2011-09
Volume
589
Issue
18
Pages
4565-4582
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2011.211094
PMC
PMC3208225
OpenAlex
W2115416024
Cited by
74
References
0
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 13 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 9 · 2013: 6 · 2012: 5
FWCI
7.53
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Physiology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (P01DK041315, R37 DK40569, R37DK040569, R01DK057236, P01DK41315)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
interstitial cells of Cajal, muscarinic receptors, M3 muscarinic receptor, calcium-activated chloride current, cholinergic stimulation, carbachol, atropine, niflumic acid, 4-DAMP, slow waves, enteric nervous system, gastrointestinal smooth muscle, pacemaker activity
MeSH terms
Animals, Atropine, Carbachol, Intestine, Small, Membrane Potentials, Mice, Inbred C57BL, Mice, Transgenic, Piperidines, Receptors, Muscarinic, Chloride Channels, Patch-Clamp Techniques, Muscarinic Agonists, Muscarinic Antagonists, Models, Animal, Green Fluorescent Proteins, Mice, Interstitial Cells of Cajal

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